The Na+/H+ exchanger isoform 1

The International Journal of Biochemistry & Cell Biology
L Fliegel

Abstract

The Na+/H+ exchanger (NHE) isoform 1 is a ubiquitously expressed integral membrane protein which regulates intracellular pH in mammalian cells. Nine isoforms of the Na+/H+ exchanger have been identified. The isoform first discovered has two domains: an N-terminal membrane domain containing approximately 500 amino acids and a C-terminal regulatory domain containing approximately 315 amino acids. The exchanger, which resides in the plasma membrane, exchanges an intracellular proton for an extracellular sodium, thereby regulating intracellular pH. It is involved in cell growth and differentiation, cell migration, and regulation of sodium fluxes. The Na+/H+ exchanger plays an important role in myocardial damage during ischemia and reperfusion and has recently been implicated as a mediator of cardiac hypertrophy. Inhibitors of the Na+/H+ exchanger, which may prove useful in the clinical treatment of these conditions, are currently being developed and clinical trials are underway.

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Citations

Nov 27, 2008·Analytical and Bioanalytical Chemistry·Ranieri BizzarriFabio Beltram
Mar 2, 2011·Basic Research in Cardiology·Fatima MraicheLarry Fliegel
Sep 22, 2010·Pflügers Archiv : European journal of physiology·Anand RotteFlorian Lang
Jun 19, 2013·Biochemical and Biophysical Research Communications·Tien Manh TranKyungpyo Park
Jun 17, 2010·The Journal of Biological Chemistry·Shigeo WakabayashiTakashi Hisamitsu
Feb 25, 2011·The Journal of Biological Chemistry·Pratap KarkiLarry Fliegel
Mar 6, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chang-Ning Liu, Chris J Somps
Jun 15, 2007·Current Opinion in Nephrology and Hypertension·Marcel E MeimaDiane L Barber
Feb 18, 2009·Journal of Gastroenterology and Hepatology·Zhan LiuMingliang Zhang
Apr 28, 2012·International Journal of Food Microbiology·T D T DangF Devlieghere
Oct 29, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xiuju LiLarry Fliegel
Aug 28, 2014·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Claudia AlvesLarry Fliegel
Dec 18, 2008·Canadian Journal of Physiology and Pharmacology·István BaczkóLarry Fliegel
Dec 10, 2008·Expert Opinion on Therapeutic Targets·Larry Fliegel
Jul 29, 2008·Connective Tissue Research·George KoliakosMartha Kaloyianni
Feb 13, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Khalid O Alfarouk
Aug 6, 2013·The Journal of Surgical Research·Xuekang YangDahai Hu
Sep 25, 2012·Biochemical and Biophysical Research Communications·Yan-Ming SunLan-Feng Wang
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Nov 13, 2010·Chemistry & Biodiversity·Mei RenGuoqing Gong
Oct 31, 2014·IUBMB Life·Ayodeji Odunewu-Aderibigbe, Larry Fliegel
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