The naive state of human pluripotent stem cells: a synthesis of stem cell and preimplantation embryo transcriptome analyses

Cell Stem Cell
Kevin HuangGuoping Fan

Abstract

Here we use a systems biology approach to comprehensively assess the conservation of gene networks in naive pluripotent stem cells (PSCs) with preimplantation embryos. While gene networks in murine naive and primed pluripotent states are reproducible across data sets, different sources of human stem cells display high degrees of variation, partly reflecting disparities in culture conditions. Finally, naive gene networks between human and mouse PSCs are not well conserved and better resemble their respective blastocysts.

References

Dec 22, 2015·Cell Stem Cell·Xiong JiRichard A Young
Oct 7, 2015·Trends in Cell Biology·Shulamit Sebban, Yosef Buganim
Mar 5, 2016·Cell Stem Cell·Yixuan Wang, Shaorong Gao
Mar 8, 2016·Cell Reports·Han QinMiguel Ramalho-Santos
Sep 8, 2015·Current Opinion in Genetics & Development·Alessandro BrombinFrançoise Jamen
Nov 28, 2015·Nature Cell Biology·Jun Wu, Juan Carlos Izpisua Belmonte
Dec 18, 2014·Cell Stem Cell·Martin F Pera
Nov 7, 2015·Cell Stem Cell·Jun Wu, Juan Carlos Izpisua Belmonte
Jun 30, 2015·Stem Cells·Benjamin T DodsworthSally A Cowley
Jun 30, 2015·Cell Stem Cell·Yongchang ChenTianqing Li
Jun 18, 2016·Cell·Jun Wu, Juan Carlos Izpisua Belmonte
Mar 24, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Daniela Ávila-GonzálezNéstor Fabián Díaz
Jun 21, 2016·Cell Stem Cell·Jin ZhangGeorge Q Daley
Jul 10, 2016·Stem Cells and Development·Ian C TobiasDean H Betts
Jul 19, 2016·Cell Stem Cell·Thorold W TheunissenRudolf Jaenisch
Jul 16, 2014·Bone·Noriyuki TsumakiAkihiro Yamashita
Apr 22, 2017·Nature Communications·S WarrierB Heindryckx
Jun 8, 2017·Stem Cell Reports·Jamie A HackettM Azim Surani
Mar 23, 2018·International Journal of Molecular Sciences·Jing SongLiang Jin
Mar 30, 2018·Nature Cell Biology·Mo Li, Juan Carlos Izpisua Belmonte
Dec 20, 2017·Development·Thorold W Theunissen, Rudolf Jaenisch
Aug 3, 2017·Development·Ge GuoAustin Smith
May 18, 2016·Development·Jun WuJuan Carlos Izpisua Belmonte
Jan 18, 2017·Development·Thorsten Boroviak, Jennifer Nichols
Apr 6, 2019·Expert Review of Proteomics·Cristina SayagoJavier Munoz
Sep 28, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna SahakyanClaire Rougeulle
May 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manling ZhangRongfeng Li
Jun 6, 2017·Human Reproduction Update·Mieke Geens, Susana M Chuva De Sousa Lopes
Mar 27, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Amanda J Collier, Peter J Rugg-Gunn
Aug 14, 2018·Science China. Life Sciences·Tianqing LiWeizhi Ji
Mar 5, 2019·Expert Opinion on Orphan Drugs·Anna M SchreiberMarek Napierala
Dec 2, 2016·Nature·Jun WuJuan Carlos Izpisua Belmonte

Citations

May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Oct 4, 2014·Cell Stem Cell·Jamie A Hackett, M Azim Surani

Related Concepts

Pluripotent Stem Cells
Genome
Murine
Mitochondria
Gene Expression Profiling
Gene Regulatory Networks
Mus
MRNA Differential Display
Metazoa
Systems Biology

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