The Nanoassembly of an Intrinsically Cytotoxic Near-Infrared Dye for Multifunctionally Synergistic Theranostics

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Ya-Fang XiaoXiao-Hong Zhang

Abstract

The combination of diagnostic and therapeutic functions in a single theranostic nanoagent generally requires the integration of multi-ingredients. Herein, a cytotoxic near-infrared (NIR) dye (IR-797) and its nanoassembly are reported for multifunctional cancer theranostics. The hydrophobic IR-797 molecules are self-assembled into nanoparticles, which are further modified with an amphiphilic polymer (C18PMH-PEG5000) on the surface. The prepared PEG-IR-797 nanoparticles (PEG-IR-797 NPs) possess inherent cytotoxicity from the IR-797 dye and work as a chemotherapeutic drug which induces apoptosis of cancer cells. The IR-797 NPs are found to have an ultrahigh mass extinction coefficient (444.3 L g-1 cm-1 at 797 nm and 385.9 L g-1 cm-1 at 808 nm) beyond all reported organic nanomaterials (<40 L g-1 cm-1 ) for superior photothermal therapy (PTT). In addition, IR-797 shows some aggregation-induced-emission (AIE) properties. Combining the merits of good NIR absorption, high photothermal energy conversion efficiency, and AIE, makes the PEG-IR-797 NPs useful for multimodal NIR AIE fluorescence, photoacoustic, and thermal imaging-guided therapy. The research exhibits the possibility of using a single ingredient and entity to perform multim...Continue Reading

References

Jan 31, 2009·Nature Reviews. Drug Discovery·Jia JiaYu Zong Chen
Aug 21, 2013·Biomaterials·Mengjiao ZhouXiaohong Zhang
Apr 24, 2016·Advanced Materials·Rajendra KurapatiAlberto Bianco
Jun 6, 2016·Advanced Drug Delivery Reviews·Yu-Wei ChenSan-Yuan Chen
Jun 6, 2016·Advanced Drug Delivery Reviews·Shawn StapletonMichael Milosevic
Jan 10, 2017·Nature Nanotechnology·Chen ZhangJianlin Shi
Jan 21, 2017·Journal of the American Chemical Society·Qianli ZouXuehai Yan
Mar 17, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Helen LeeBart S Hendriks
Jul 8, 2017·ACS Nano·Qi LeiXian-Zheng Zhang
Jul 29, 2017·Advanced Materials·Chaoliang TanHua Zhang
Feb 2, 2018·Advanced Materials·Joël BourquinBarbara Rothen-Rutishauser
Mar 13, 2018·Chemical Society Reviews·Hyo Sung JungJong Seung Kim
Jul 22, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jinzhao LiuQiang Peng
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen

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Citations

Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Jun 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhonghua LiuYongwei Huang
Jun 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzhen LiXin Ding
Aug 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xueping KongLixin Wu
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chen ZhaoHaifeng Liu
Apr 8, 2020·European Journal of Medicinal Chemistry·Mengjiao ZhouFeifei An
Jun 30, 2021·Journal of Nanobiotechnology·Jingqi XinFeifei An
May 17, 2021·Ultrasound in Medicine & Biology·Ranran GuoPeng Zhang
Aug 21, 2021·Advanced Healthcare Materials·Jun DaiShixuan Wang
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Muling ZengEudald Casals
Oct 30, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Feifei AnRichard Ting

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