The Na+/PO4 cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos

Gene Expression Patterns : GEP
Massimo NichaneEric J Bellefroid

Abstract

The embryonic pronephric kidneys of Xenopus and zebrafish serve as models to study vertebrate nephrogenesis. Recently, multiple subdomains within the Xenopus pronephros have been defined based on the expression of several transport proteins. In contrast, very few studies on the expression of renal transporters have been conducted in zebrafish. We have recently shown that the anterior and posterior segments of the zebrafish pronephric duct may correspond to the proximal tubule and distal tubule/duct compartments of the Xenopus and higher vertebrate pronephros, respectively. Here, we report the embryonic expression pattern of the Na(+)/PO(4) cotransporter SLC20A1 (PiT1/Glvr-1) gene encoding a type III sodium-dependent phosphate cotransporter in Xenopus and zebrafish. In Xenopus, SLC20A1 mRNA is expressed in the somitic mesoderm and lower level of expression is detected in the neural tube, eye, and neural crest cells. From stage 25, SLC20A1 is also detectable in the developing pronephros where expression is restricted to the late portion of the distal pronephric tubules. In zebrafish, SLC20A1 is transcribed from mid-somitogenesis in the anterior part of the pronephros where its expression corresponds to the rostral portion of the ...Continue Reading

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Citations

Apr 27, 2011·Current Opinion in Nephrology and Hypertension·Lwaki EbarasiKarl Tryggvason
Jul 25, 2009·American Journal of Physiology. Cell Physiology·Caroline R SussmanMin-Hwang Chang
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Jul 25, 2019·Molecular Reproduction and Development·Xianbo ZhangDeshou Wang
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Aug 28, 2020·Frontiers in Cell and Developmental Biology·Johanna Magdalena RiekeHeiko Reutter
Mar 23, 2021·Science China. Life Sciences·Jiakui ChenYiyue Zhang

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