The nasal microbiota in health and disease: variation within and between subjects

Frontiers in Microbiology
Kristi BiswasRichard G Douglas

Abstract

Chronic rhinosinusitis (CRS) affects approximately 5% of the adult population in Western societies and severely reduces the patient's quality of life. The role of bacteria in the pathogenesis of this condition has not yet been established with certainty. However, recent reports of bacterial and fungal biofilms in CRS highlight a potential role for these microorganisms. In this study, 16S rRNA gene-targeted amplicon pyrosequencing and qPCR were used to determine the composition and abundance, respectively, of the sinus microbiota within 9 patients with CRS and 6 healthy individuals. Within-patient variability was also investigated by sampling from anterior nares, inferior turbinate, and middle meatus on each side of the sinuses. Our results indicate that more of the variation in bacterial composition can be explained by inter-personal differences, rather than sampling location or even disease status. In addition, bacterial community diversity was significantly lower in CRS samples compared to those from healthy subjects, whereas bacterial load was not associated with disease status. Although members of the genera Corynebacterium and Staphylococcus were prevalent in the majority of samples (including healthy subjects), the large ...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R E Gliklich, R Metson
Oct 6, 1998·Applied and Environmental Microbiology·M F Polz, C M Cavanaugh
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·N F RayY H Pung
Dec 5, 2003·Nucleic Acids Research·Xiaowei Wang, Brian Seed
Aug 19, 2004·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Jonathan CryerJames N Palmer
Oct 29, 2004·The Laryngoscope·Stilianos E KountakisLarry Borish
Oct 27, 2006·American Journal of Rhinology·Alessandro de AlarcónLarry Borish
Aug 30, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Stephanie A JoeJie Huang
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 23, 2009·The Laryngoscope·Neil Bhattacharyya
Mar 3, 2009·Genome Research·Ivan NasidzeMark Stoneking
May 30, 2009·Science·Elizabeth A GriceJulia A Segre
Oct 13, 2009·Journal of Biotechnology·Young Mi KimJong Moon Park
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Dec 5, 2009·American Journal of Rhinology & Allergy·Andrew ForemanPeter-John Wormald
Jul 16, 2010·The ISME Journal·Adam M GussColleen M Cavanaugh
Sep 2, 2010·World Journal of Gastroenterology : WJG·Carlos W NossaZhiheng Pei
Sep 10, 2010·The ISME Journal·Catherine LozuponeRob Knight
Aug 27, 2011·The Journal of Allergy and Clinical Immunology·Koen Van CrombruggenClaus Bachert
Oct 29, 2011·The Laryngoscope·Zachary M SolerTimothy L Smith
Jan 19, 2012·The Laryngoscope·Leah M FeazelDaniel N Frank
Feb 11, 2012·Current Allergy and Asthma Reports·Andrew ForemanPeter-John Wormald
May 15, 2012·Nature Reviews. Microbiology·China A HansonJennifer B H Martiny
Oct 12, 2012·International Forum of Allergy & Rhinology·Vijay R RamakrishnanDaniel N Frank
May 10, 2013·BMC Infectious Diseases·Sam BoasePeter-John Wormald
Jul 11, 2013·Applied Microbiology and Biotechnology·Kristi BiswasSusan J Turner
Jul 12, 2013·International Forum of Allergy & Rhinology·Cindy M LiuAndrew P Lane
Sep 3, 2013·The Journal of Allergy and Clinical Immunology·Grazyna BochenekEwa Nizankowska-Mogilnicka
Nov 2, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Rajeev AuroraThomas Sanford
Dec 5, 2013·Current Opinion in Allergy and Clinical Immunology·Jeong-Hee ChoiHae-Sim Park
Jan 5, 2014·PloS One·Vijay R RamakrishnanDaniel N Frank
Jan 15, 2014·International Forum of Allergy & Rhinology·Edward John ClelandPeter-John Wormald
Aug 22, 2014·Microbiome·Christine M BassisMelissa A Pynnonen
Jan 1, 2010·Allergy & Rhinology·Andrew ForemanPeter-John Wormald

❮ Previous
Next ❯

Citations

Dec 27, 2017·International Forum of Allergy & Rhinology·Michael HoggardBenjamin S Bleier
Jan 30, 2018·Frontiers in Cellular and Infection Microbiology·Do-Yeon ChoBradford A Woodworth
Jun 10, 2018·Postgraduate Medical Journal·James Jordan Johnston, Richard Douglas
Aug 5, 2016·Journal of Clinical Microbiology·Michel NeeffRichard Douglas
Dec 3, 2016·Clinical Microbiology Reviews·Michael HoggardRichard G Douglas
Jan 22, 2019·The Laryngoscope·Saeed AlsharifClaus Bachert
May 23, 2018·Scientific Reports·Thanit ChalermwatanachaiClaus Bachert
Oct 13, 2017·Nature Reviews. Microbiology·Bernhard KrismerAndreas Peschel
Aug 9, 2017·Current Allergy and Asthma Reports·Alkis J Psaltis, Peter-John Wormald
Jan 12, 2020·FEMS Microbiology Ecology·Connie A RojasKevin R Theis
Aug 27, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Anna Heintz-BuschartPaul Wilmes
Sep 23, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weigang GanJuan Meng
Jul 29, 2015·International Forum of Allergy & Rhinology·Raymond J T KimRichard G Douglas
Jun 17, 2016·International Forum of Allergy & Rhinology·Nithin D AdappaNoam A Cohen
May 22, 2016·Environmental Microbiology·Melissa L Wos-OxleyDietmar H Pieper
Sep 15, 2016·International Forum of Allergy & Rhinology·Vijay R RamakrishnanDaniel N Frank
Aug 22, 2018·Allergy & Rhinology·Vijay R RamakrishnanDaniel N Frank
Apr 24, 2020·Frontiers in Cellular and Infection Microbiology·Ahmed BassiouniAlkis J Psaltis
Aug 30, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weigang GanJunming Xian
Nov 20, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sultan Şevik EliçoraCanan Külah
Mar 31, 2016·International Forum of Allergy & Rhinology·Ravi JainRichard Douglas
Jul 1, 2017·PloS One·Elisabeth S DornBianka S Schulz
May 15, 2018·Frontiers in Microbiology·Kerstin KoellerBernhard Olzowy
Sep 1, 2018·BMC Infectious Diseases·Ioannis KoutsourelakisAndrew P Lane
Sep 5, 2019·International Forum of Allergy & Rhinology·Brett Wagner MackenzieKristi Biswas
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Sep 20, 2016·International Forum of Allergy & Rhinology·Ravi JainRichard Douglas
Apr 29, 2020·Journal of Oral Microbiology·Jessica A P Carlson-JonesJames G Mitchell
Nov 24, 2016·International Forum of Allergy & Rhinology·Michael HoggardRichard G Douglas
Dec 23, 2017·Frontiers in Cellular and Infection Microbiology·Kristi BiswasRichard G Douglas

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