Abstract
Cancer stem-like cells (CSC) are regarded as the source of tumour origins, metastasis and drug resistance, and limits current treatment regimens. Previously, we reported the first study of the anti-angiogenic and anti-tumour activities of 4-vinylphenol. To further examine the therapeutic role of 4-vinylphenol, the inhibitory effects of 4-vinylphenol on cancer stemness, drug resistance and metastasis in breast cancer were investigated in the present study. We enriched parental MDA-MB-231 cells with CSCs in serum-free medium to give spheroids. The effects of 4-vinylphenol on cancer stemness, metastasis and drug resistance in CSC-enriched MDA-MB-231 cells were studied in vitro and in vivo. CSC-enriched MDA-MB-231 cells demonstrated higher tumorigenic and metastatic potential. 4-Vinylphenol reduced spheroid formation and ALDH1 expression in CSC-enriched cultures, revealing its inhibitory effects on the traits of CSCs. 4-Vinylphenol suppressed colony formation and cell proliferation. 4VP also inhibited in vitro invasion and in vivo metastasis in zebrafish model. Our results showed that it reduced vimentin expression, suppressed cell migration, affected the expression and/or activity of MMPs, TIMPs and uPA. In addition, the expressio...Continue Reading
References
Mar 10, 2001·Nature·A MüllerA Zlotnik
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Oct 26, 2006·Breast Cancer Research : BCR·Carol SheridanHarikrishna Nakshatri
Mar 29, 2008·Cell Stem Cell·Patrick C HermannChristopher Heeschen
May 20, 2008·Cell·Sendurai A ManiRobert A Weinberg
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheong J LeeDiane M Simeone
Aug 7, 2008·Journal of Cellular and Molecular Medicine·Alysha K CrokerAlison L Allan
Aug 13, 2008·Journal of the National Cancer Institute·Abenaa M BrewsterFrancisco J Esteva
Feb 4, 2009·Letters in Applied Microbiology·L GodoyM A Ganga
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomonori TaneiShinzaburo Noguchi
Aug 18, 2009·Cell·Piyush B GuptaEric S Lander
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emmanuelle Charafe-JauffretMax S Wicha
Feb 1, 2011·Stem Cells·Paola MarcatoPatrick W K Lee
May 30, 2012·Oncology Reports·Xu-Zheng ChenJian Du
Jun 19, 2012·Cell Stem Cell·Jane E Visvader, Geoffrey J Lindeman
Jan 8, 2013·International Journal of Oncology·Jiumao LinJun Peng
May 2, 2013·Cancer Cell International·Jo-Anne de la MareAdrienne L Edkins
Sep 27, 2013·Biotechnology Letters·Pauline FrasJosé António Couto
Oct 5, 2013·BMC Cancer·Yong TengJohn K Cowell
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 9, 2015·Biochimica Et Biophysica Acta·Hoi-Wing LeungNing-Hua Tan
Jun 9, 2015·Scientific Reports·Grace Gar-Lee YueClara Bik-San Lau
Jun 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui ChenMenghua Liu