The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates

Microbial Pathogenesis
Jawad BehbehaniMaribassapa Karched

Abstract

The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp. (four standard and 60 oral isolates) through minimum inhibitory concentration (MIC) and growth curve assays. Insight into the mechanisms of the antifungal action has been gained through ultrastructural studies using confocal scanning laser microscopy (CSLM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Molecular docking was done for predicting the interactions of magnolol with ergosterol at supramolecular level. The toxicity of magnolol on human erythrocytes was measured by in vitro hemolytic assay. MIC values of magnolol ranged from 16-64 μg/ml, respectively. All tested isolates showed a marked sensitivity towards magnolol in growth curve ...Continue Reading

Citations

Feb 13, 2018·The Journal of Pharmacy and Pharmacology·Hongxue ShenGuohui Liang
Oct 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriel MarcOvidiu Oniga
Feb 25, 2019·Lasers in Medical Science·Chiaki Tsutsumi-AraiKazuhito Satomura
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Oct 31, 2020·Journal of the Science of Food and Agriculture·Dongmei JiangMeng Wang
Apr 6, 2021·Frontiers in Pharmacology·Yiping LinYing Song
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Sep 18, 2021·Phytotherapy Research : PTR·Fahimeh NourbakhshVahid Soheili
Sep 29, 2021·Journal of Agricultural and Food Chemistry·Hu LiYin-Fang Yan

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