PMID: 16614421Apr 15, 2006Paper

The natural concentration of the conjugated linoleic acid, cis-9,trans-11, in milk fat has antiatherogenic effects in hyperlipidemic hamsters

The Journal of Nutrition
Karine ValeilleJean-Charles Martin

Abstract

Milk fat is usually considered to be proatherogenic, although its fatty acid composition can vary, due mainly to farming conditions. No study has evaluated whether such variation can modify the atherogenic properties of dairy fat. Aortic lipid deposition and related risk factors were examined in Syrian hamsters fed diets for 12 wk containing 200 g/kg of 2 commercial milk fats [high content of saturated fatty acids (HSF) and low content of saturated fatty acids (LSF)] contrasting, respectively, in total saturated fatty acids (72 vs. 67 g/100 g), 18:1, trans (4.24 vs. 7.26 g/100g), and conjugated linoleic acid (mainly cis-9,trans-11 or rumenic acid; 0.39 vs. 2.59 g/100 g). Hamsters fed the LSF-diet had 25% less aortic cholesteryl-ester deposition than those fed the HSF-diet; this was accompanied by an improved plasma cholesterol profile (lower LDL cholesterol and LDL:HDL cholesterol ratio), a lower local inflammatory status (aortic gene expression of cyclooxygenase-2), and lower aortic gene expression of vascular cell adhesion molecule-1 (all P < 0.05). Supplementation of the LSF-diet with rumenic acid (up to 9 g/kg) amplified the antiatherogenic effect of the original LSF-diet compared with the HSF-diet, i.e., less aortic choles...Continue Reading

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Citations

Jun 1, 2012·Molecular Nutrition & Food Research·Eva-Maria BachmairBaukje de Roos
Jun 17, 2014·The British Journal of Nutrition·Bérengère BenoitMarie-Caroline Michalski
Aug 30, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Patricia L Mitchell, Roger S McLeod
Jul 23, 2009·The British Journal of Nutrition·Robert Ringseis, Klaus Eder
Feb 3, 2012·Nutrition Research Reviews·Tracy A McCrorieM Barbara E Livingstone
May 31, 2011·Journal of Asian Natural Products Research·Yang SunHai-Bo Zhu
Sep 10, 2014·The Proceedings of the Nutrition Society·Elaine PattersonCatherine Stanton
Dec 21, 2011·Pharmaceutical Biology·Yassir Mohammed AliMuhammed Nazrul Hakim Abdullah
Aug 30, 2017·Nutritional Neuroscience·Francesca SabaSebastiano Banni
Jun 14, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Jean-Charles MartinBernadette Delplanque
Nov 20, 2009·The American Journal of Clinical Nutrition·Ivonne SluijsMichiel L Bots
Nov 23, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·James C Russell, Spencer D Proctor
Aug 23, 2008·Nutrition & Metabolism·Yukiko K NakamuraStanley T Omaye

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