The natural course of cutaneous melanoma

Journal of Surgical Oncology
Ulrike LeiterClaus Garbe

Abstract

The natural course of cutaneous melanoma (CM) is determined by its metastatic spread and depends on tumor thickness, ulceration, gender, localization, and the histologic subtype of the primary tumor. CM metastasis develops via three main metastatic pathways and occurs as satellite or in-transit metastasis, as regional lymph node metastasis or as distant metastasis at the time of primary recurrence. About 50% of all CM patients with tumor progression firstly develop regional lymph node metastases. In the other 50% the first metastases are satellite or in-transit metastases (about 20%), or immediately distant metastases (about 30%). Development of distant metastasis appears to be an early event in metastatic spread and may in the majority of cases originate from the primary tumor, only few cases may develop secondarily to locoregional metastasis. Reporting of organ involvement in distant metastasis greatly differs between the results of imaging techniques and autopsy results in respect to the metastatic patterns detected, pointing out that there is a need of improved imaging systems. Proliferation, neovascularization, lymphangiogenesis, invasion, circulation, and embolism are important steps in the pathogenesis of CM metastasis, ...Continue Reading

References

Apr 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D R BudmanR E Wittes
Jun 1, 1978·American Journal of Surgery·J K PatelR H Moore
Nov 1, 1992·Seminars in Surgical Oncology·C M Balch
Jan 11, 1992·Annals of Plastic Surgery·D S ReintgenH F Seigler
Sep 1, 1991·American Journal of Surgery·J K Ihde, D G Coit
Feb 1, 1992·AJR. American Journal of Roentgenology·A PremkumarD Schwartzentruber
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M TillmanR M MacKie
Jun 1, 1991·Archives of Surgery·J S MarkowitzA B Cosimi
Mar 1, 1990·Archives of Surgery·D CoitM Brennan
Aug 1, 1990·Annals of Surgery·R G BevilacquaM F Brennan
Aug 1, 1988·The Journal of Dermatologic Surgery and Oncology·I J Fidler
Feb 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ R Durant
Jan 15, 1995·Cancer·A Barth, D L Morton
Jan 1, 1993·Plastic and Reconstructive Surgery·S FusiA Sternlicht
Feb 1, 1996·Nature Medicine·J Folkman
Apr 1, 1996·AJR. American Journal of Roentgenology·V G McDermottE K Paulson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·J LeeW I Wood
Dec 27, 1996·Cell·J Folkman, P A D'Amore
May 30, 1997·Science·M JeltschK Alitalo
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Nov 24, 1999·Annals of Surgical Oncology·P I HaighD L Morton
Dec 22, 1999·The American Journal of Gastroenterology·D BleckerM L Kochman
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J ManolaJ Kirkwood
Nov 23, 2000·Journal of Surgical Oncology·P SavoiaM G Bernengo
Feb 7, 2001·Archives of Ophthalmology·T Mäkitie, T Kivelä
Feb 15, 2001·Nature Medicine·S A StackerM G Achen
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Dec 18, 2001·Chest·T Mäkitie, T Kivelä

❮ Previous
Next ❯

Citations

Jun 18, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Callejo Peixoto, José Meneses e Sousa
Jul 10, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jonathan D SolomonRalph C Eagle
Jun 12, 2012·Cancer Metastasis Reviews·Aaron K MobleyMenashe Bar-Eli
Dec 26, 2008·The New England Journal of Medicine·Anne C Chiang, Joan Massagué
Jun 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·Nuria AlvarezCristina Martínez
Jul 12, 2013·Carcinogenesis·María Contador-TrocaPedro M Fernández-Salguero
Nov 18, 2010·Journal of the National Cancer Institute·Yan XingJanice N Cormier
Jun 5, 2007·Journal of Clinical Pathology·Henna Anu-Liisa OittinenCatherine Keohane
Aug 31, 2011·Dermatology Research and Practice·Yan XingJanice N Cormier
Sep 25, 2009·Annals of Surgical Oncology·R Taylor RipleyItzhak Avital
Jun 11, 2011·Biomarkers in Medicine·Konstantinos LinosJ Andrew Carlson
Jan 8, 2013·World Journal of Hepatology·Shun-Da DuJie-Fu Huang
Apr 1, 2014·Virchows Archiv : an International Journal of Pathology·Gergo KisznerTibor Krenacs
Jul 16, 2010·Dermatology Research and Practice·Thomas van den BoschAnnelies de Klein
Sep 26, 2009·Cancer Immunology, Immunotherapy : CII·Maria NapolitanoStefania Scala
Sep 24, 2014·The Surgical Clinics of North America·Iris H WeiSandra L Wong
Jun 1, 2008·Clinical Journal of Gastroenterology·Kotaro ShibagakiYoshikazu Kinoshita
Jul 18, 2012·Dermatologic Clinics·Clay J Cockerell
Apr 13, 2012·The Journal of Surgical Research·Minhyung KimJoseph J Skitzki
Sep 14, 2011·Current Problems in Cancer·Miguel A MaterinHarriet M Kluger
Nov 26, 2010·Cancer Treatment Reviews·Andrianos NezosMichael Koutsilieris
Dec 20, 2008·Revista española de medicina nuclear·J Ortín-PérezF Pons
Jan 28, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Cristina Martínez ConesaMatilde Campos Aranda
Apr 25, 2006·Surgical Oncology Clinics of North America·Richard EssnerEinat Even-Sapir
Jan 2, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R SiegelP M Schlag
Nov 22, 2005·Dermatologic Therapy·Cristiane Benvenuto-AndradeAshfaq A Marghoob
Nov 6, 2007·Journal of Cellular and Molecular Medicine·G PalmieriA Cossu
Jul 3, 2013·Journal of Surgical Oncology·Seung Wook RyuCharbel Sandroussi
Jun 19, 2013·The British Journal of Surgery·J-M AubinG Martel
Jul 1, 2014·Cancer·Andrew J PageTimothy M Pawlik

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