The natural course of progressive systemic sclerosis patients with interstitial lung involvement.

Clinical Rheumatology
Musellim BenanOngen Gul

Abstract

The aim of the study is to assess the natural course of systemic sclerosis (SSc) in patients with interstitial lung involvement and to evaluate the effects of treatment. Sixty SSc patients with interstitial lung involvement were included in the study and history and retrospective data records of the patients were reviewed. It was observed that 47 patients (78.3%) had Raynaud's phenomenon, 7 patients (11.7%) had skin involvement, 5 patients (8.3%) had joint involvement, and 1 patient (1.7%) had gastrointestinal system involvement as the first manifestation of the disease. Lung involvement had developed on an average of 113 +/- 106 months after the first manifestation of the disease and was apparent within the first year in 10 patients (16.7%), between 1 and 2 years in 3 patients (5%), between 2 and 3 years in 2 patients (3.3%), between 3 and 4 years in 5 patients (8.3%), between 4 and 10 years in 21 patients (35%), and after 10 years in 19 patients (31.7%). When the symptoms of lung involvement appeared, 37 patients (61.7%) were not receiving treatment while 23 (38.3%) were using an immunosuppressive agent. The time interval of lung involvement for the treated patients was 131 +/- 95 months while it was 101 +/- 112 months in unt...Continue Reading

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Citations

May 25, 2010·Rheumatology International·Hadi PoormoghimFaezeh Sodagari
Nov 1, 2013·Current Rheumatology Reports·Shannon HaleyRoss Summer
Jan 3, 2012·Paediatric Respiratory Reviews·C Egla Rabinovich
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Oct 25, 2016·Autoimmunity Reviews·Adriana Morales-CárdenasJuan-Manuel Anaya
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Jun 21, 2021·Reumatología clinica·Abeer M GhandourHanan Sayed M Abozaid

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