The natural history of aberrant crypt foci

Gastrointestinal Endoscopy
Robert E SchoenPaul F Pinsky

Abstract

Aberrant crypt foci (ACF) are the putative precursors to colorectal adenomas and may be useful as biomarkers. Knowledge of their natural history is essential to understanding their potential utility. Our purpose was to examine ACF detection 1 year after initial observation. We conducted a multicenter study of ACF by using a standardized protocol. ACF in the rectum were assessed and subjects returned 1 year later to evaluate the natural history of the lesions. Ancillary study to the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Of 78 subjects enrolled, 64 (82%) returned for a repeat examination 1 year later. The mean age was 71 years, 70% were male, and 54% had a history of adenomatous polyps. At the initial examination, 66% of subjects had at least 1 ACF detected in the rectum, with a mean of 2.1 +/- 2.3 per person. One year later, 60% of these subjects had at least 1 of the original ACF reidentified, but only 43% of all ACF were reidentified. A total of 56% of subjects had new ACF identified. These results are generated from the pilot phase. Improvements or change in technique over time could have influenced the results. A total of 60% of subjects who had ACF continued to have at least one ACF 1 year later, b...Continue Reading

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Citations

Dec 11, 2008·Cancer Causes & Control : CCC·Helen SwedeDaniel W Rosenberg
Dec 21, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M Lopez-Ceron, M Pellise
Jun 24, 2010·Cancer Prevention Research·Paul F PinskyRobert E Schoen
Jan 7, 2011·Cancer Prevention Research·Paul J LimburgUNKNOWN Cancer Prevention Network
Jan 8, 2013·World Journal of Gastrointestinal Endoscopy·Hirokazu TakahashiAtsushi Nakajima
Aug 13, 2013·Gastroenterology Clinics of North America·Deepika DevuniJoseph C Anderson
Sep 14, 2010·Best Practice & Research. Clinical Gastroenterology·Mauro Risio
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Mauro Risio
Jun 23, 2009·Gastrointestinal Endoscopy·Akshay K GuptaRobert E Schoen
Oct 1, 2008·Gastrointestinal Endoscopy·Shin ei KudoPaul D Hurlstone
Jun 3, 2008·Gastrointestinal Endoscopy·Shaheen Rasheed, Basil Rigas
May 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Matthew G MutchPaul F Pinsky
Mar 18, 2010·The American Journal of Gastroenterology·Joseph C AndersonDaniel W Rosenberg
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Mar 21, 2009·Expert Review of Molecular Diagnostics·Kjetil SøreideHartwig Kørner
May 29, 2019·Clinical and Translational Gastroenterology·Isabel QuintanillaMaria Pellisé

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