The natural history of chronic obstructive pulmonary disease

The European Respiratory Journal
D M ManninoJ Vestbo

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in the USA, and it remains one of the few diseases that continues to increase its numbers. The development and progression of COPD can vary dramatically between individuals. A low level of lung function remains the cornerstone of COPD diagnosis and is a key predictor of prognosis. Lung function, however, is not the only factor in determining morbidity and mortality related to COPD, with factors such as body mass index, exercise capability and comorbid disease being important predictors of poor outcomes. Exacerbations of COPD are additional important indicators of both quality of life and outcomes in COPD patients. Definitions of exacerbations can vary, ranging from an increase in symptoms to COPD-related hospitalisations and death. COPD exacerbations are more common in patients with lower levels of lung function and may lead to more rapid declines in lung function. Better understanding of the natural history of COPD may lead to better definitions of specific COPD phenotypes, better interventions and improved outcomes.

Citations

Apr 13, 2013·Drugs & Aging·Timothy E AlbertsonAndrew L Chan
Sep 10, 2011·The Journal of Biological Chemistry·Christine U VohwinkelJacob I Sznajder
Feb 18, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathleen M AkgünMargaret Pisani
Aug 30, 2008·Thorax·S E MarshR W Beasley
Oct 6, 2012·Respiration; International Review of Thoracic Diseases·R H J SlenterG G U Rohde
Apr 7, 2007·American Journal of Respiratory and Critical Care Medicine·Sigal Ben-Zaken CohenDon D Sin
Aug 21, 2008·American Journal of Respiratory and Critical Care Medicine·Antonello PunturieriJames P Kiley
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Robab KohansalJoan B Soriano
Mar 16, 2013·American Journal of Respiratory and Critical Care Medicine·G Brooke AndersonRoger D Peng
Jul 28, 2012·The European Respiratory Journal·Jadwiga A WedzichaTerence A R Seemungal
Nov 16, 2013·BMC Medicine·Adam K H Usher, Robert A Stockley
Sep 6, 2013·Multidisciplinary Respiratory Medicine·Michela BellocchiaCaterina Bucca
Sep 18, 2013·Multidisciplinary Respiratory Medicine·Aylin Ozgen AlpaydinArzu Yorgancioglu
Feb 12, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Richard RussellIdelle Weisman
Dec 28, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Abdulsalam M AlaithanAbdul Salam
Jun 26, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Sean H Ling, Stephan F van Eeden
Dec 27, 2013·Asian Journal of Andrology·I-Nae ParkTae Beom Kim
Dec 21, 2012·Proceedings of the American Thoracic Society·Leonardo M FabbriUNKNOWN ATS/ERS Ad Hoc Committee on Integrating and Coordinating Efforts in COPD Guideline Development
Jan 16, 2014·Annals of the American Thoracic Society·Himanshu DesaiSanjay Sethi
Oct 16, 2008·Scandinavian Journal of Infectious Diseases·Mette V LarsenPeter Lange
May 20, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Hakki KayaMehmet Birhan Yilmaz
Oct 17, 2015·American Journal of Respiratory Cell and Molecular Biology·Robert P YoungBenjamin Marsland
Jan 7, 2011·Chest·Yvonne Nussbaumer-Ochsner, Klaus F Rabe
May 24, 2007·Revue des maladies respiratoires·P Escourrou, J C Meurice
Sep 4, 2007·Lancet·Leonardo M Fabbri, Klaus F Rabe
Oct 1, 2008·The Clinical Respiratory Journal·Claes-Göran Löfdahl
Apr 12, 2014·BioMed Research International·Cheryl R Laratta, Stephan van Eeden
May 3, 2016·Expert Review of Respiratory Medicine·Konstantinos KostikasFrancesco Patalano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.