The natural history of community-acquired common colds symptoms assessed over 4-years.

Rhinology
T J WitekDonald K Riker

Abstract

The common cold is the most frequently experienced infection among humans, but limited data exist to characterize the onset, duration, severity and intersection of symptoms in community-acquired colds. A more complete understanding of the symptom frequency and burden in naturally occurring colds is needed. We characterized common cold symptoms from 226 cold episodes experienced by 104 male or female subjects. Subjects were enrolled in the work environment in an attempt to start symptom evaluation (frequency and severity) at the earliest sign of their cold. We also assessed the symptom that had the greatest impact on the subject by asking them to identify their single most bothersome symptom. Symptom reporting started within 24 hours of cold onset for most subjects. Sore throat was a harbinger of the illness but was accompanied by multiple symptoms, including nasal congestion, runny nose and headache. Cough was not usually the most frequent symptom, but was present throughout the cold, becoming most bothersome later in the cold. Nasal congestion, pain (eg, sore throat, headache, muscle pains) or feverishness and secretory symptoms (eg, runny nose, sneezing), and even cough, were simultaneously experienced with high incidence ove...Continue Reading

Citations

Oct 12, 2018·BMJ : British Medical Journal·Mieke L van DrielAn De Sutter
Oct 31, 2020·ERJ Open Research·Samantha K AtkinsonLaura R Sadofsky
Oct 7, 2021·Expert Review of Respiratory Medicine·De Yun WangYong Chiat Wong

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