The natural history of depression and trajectories of symptoms long term after stroke: The prospective south London stroke register

Journal of Affective Disorders
S AyisCharles D A Wolfe

Abstract

The natural history of depression in stroke patients is complex and the mechanism of change in symptoms over time is not fully understood. We hypothesise that there are different trajectories of symptoms after stroke. The primary analysis comprised 761 patients who completed 5 years follow up, obtained from the prospective South London Stroke Register (1998-2013). The Hospital Anxiety and Depression scale (HADs) was used to screen patients for depression symptoms at 3 months after stroke, then annually. Trajectories of depression symptoms were detected using group based trajectory modelling (GBTM). Four patterns of symptoms (Groups I-IV) were identified: 6.31% of patients had severe symptoms, improved slightly in early years then worsen (predicted mean HADs score, 15.74 (se=1.06)); 28.65% had moderate symptoms, a tendency to get worse over time, predicted mean score 7.36 (se=0.35); 49.54% had mild symptoms and a tendency of getting worse, predicted mean 3.89 (se=0.30), and 15.51% of the cohort, had no symptoms and remained so over time. The lowest rate of Selective serotonin reuptake inhibitors (SSRI) use, over 5 years after stroke was 1.1% for group (I) and highest was 35% for group (IV). Sensitivity analyses were used to asse...Continue Reading

References

Oct 1, 1991·Stroke; a Journal of Cerebral Circulation·C D WolfeP G Burney
Aug 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·D T WadeR A Hewer
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·B Muthén, L K Muthén
Feb 1, 2002·International Journal of Epidemiology·K TillingC D Wolfe
Sep 6, 2007·Psychological Methods·Amelia HavilandPaul R Rosenbaum
Dec 7, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Eric Emerson, Chris Hatton
Jan 25, 2008·Drug and Alcohol Dependence·C Hendricks BrownUNKNOWN Prevention Science and Methodology Group
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Peter U HeuschmannCharles D A Wolfe
Mar 3, 2010·Annual Review of Clinical Psychology·Daniel S Nagin, Candice L Odgers
Dec 7, 2010·Journal of Quantitative Criminology·Daniel S Nagin, Candice L Odgers
Mar 29, 2011·Stroke; a Journal of Cerebral Circulation·Christopher McKevittCharles D A Wolfe
Aug 4, 2011·BMJ : British Medical Journal·Carol CouplandJulia Hippisley-Cox
Jun 26, 2012·Disability and Rehabilitation·N B LincolnL De Wit
Sep 12, 2012·Annals of Family Medicine·Jennifer H WhiteMichael Pollack
Jan 4, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Luis AyerbeAnthony G Rudd
Feb 7, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Nick MeaderAlex J Mitchell
Feb 14, 2013·Stroke; a Journal of Cerebral Circulation·Luis AyerbeAnthony G Rudd
Dec 18, 2013·Development and Psychopathology·Terrie E Moffitt, UNKNOWN Klaus-Grawe 2012 Think Tank
Aug 15, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Maree L Hackett, Kristen Pickles

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Citations

Jan 8, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S A AyisC D A Wolfe
Jan 30, 2021·Seminars in Neurology·Katlyn Nemani, Lindsey Gurin
Mar 18, 2021·Journal of Neural Transmission·Anna Maria LopatkiewiczTomasz Dziedzic
Jun 30, 2021·Journal of the American Heart Association·Liming DongLynda D Lisabeth

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