The natural history of late-stage "pure" semantic dementia

Neurocase
Elizabeth JefferiesMatthew A Lambon Ralph

Abstract

Relatively little is known about the neuropsychological profile of late-stage semantic dementia. This article provides a detailed assessment of patient MK who, despite her very severe semantic impairments, remained cooperative to testing and, unusually, did not show additional behavioral/personality changes. Although MK's initial presentation was typical of semantic dementia (SD), her performance began to deviate from the normal pattern. She developed impairments of single word repetition and regular word reading, and began to produce phonological errors in picture naming and spontaneous speech. These deficits might suggest that late-stage SD includes an independent disorder of phonology. An alternative possibility, however, is that phonological processing cannot proceed normally in the face of profound semantic degradation. A series of experiments supported the latter explanation of MK's deficits. In picture naming, MK showed little effect of progressive phonological cueing, did not reveal an increased sensitivity to word length or phonological complexity and continued to show a high degree of item-specific consistency in both accuracy and errors: she tended to produce the same erroneous phonemes for each item. She remained se...Continue Reading

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Citations

Jul 21, 2004·Cognitive, Affective & Behavioral Neuroscience·Elizabeth JefferiesMatthew A Lambon Ralph
May 25, 2010·Journal of Communication Disorders·Jamie ReillyJean Neils-Strunjas
Mar 17, 2009·Brain and Cognition·Marco CalabriaMaria Cotelli
Apr 29, 2008·Journal of Memory and Language·Elizabeth JefferiesMatthew A Lambon Ralph
Sep 17, 2013·International Journal of Language & Communication Disorders·Jacqueline KindellRay Wilkinson
Oct 27, 2007·Neuropsychologia·Elizabeth JefferiesMatthew A Lambon Ralph
Nov 27, 2008·Journal of the Neurological Sciences·Jonathan D RohrerJason D Warren
Aug 19, 2020·American Journal of Speech-language Pathology·Jara StalpaertMiet De Letter

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