The natural history of latent rheumatic heart disease in a 5 year follow-up study: a prospective observational study

BMC Cardiovascular Disorders
Liesl ZühlkeBongani M Mayosi

Abstract

Latent rheumatic heart disease (RHD) occurs in asymptomatic individuals with echocardiographic evidence of RHD and no history of acute rheumatic fever. The natural history of latent RHD is unclear but has important clinical and economic implications about whether these children should receive penicillin prophylaxis or not. We performed a 5-year prospective study of this question. In August 2013 through September 2014, we conducted a follow-up study of latent RHD among school pupils using the World Heart Federation (WHF) echocardiographic criteria. Contingency tables were used to assess progression, persistence or regression of latent RHD. Forty two borderline and 13 definite cases of RHD (n 55) were identified, 44 (80%; mean age 13.8 ± 4.0 years; 29 (65.9%) female) of whom were available for echocardiographic examination at a median follow-up of 60.8 months (interquartile range 51.3-63.5). Over the follow-up period, half the participants (n = 23; 52.3%) improved to normal or better WHF category (regressors), a third (n = 14, 31.8%) remained in the same category (persistors), while seven others (15.9%) progressed from borderline to definite RHD (progressors). In total, 21 subjects (47.7%) reverted to a normal status, nine (20.4%...Continue Reading

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Citations

Sep 9, 2016·Journal of Global Health·Gabriele Rossi, Vivian Sau Wai Lee
Apr 13, 2017·International Journal of Cardiology·Daniel EngelmanAndrew C Steer
Mar 13, 2017·Current Treatment Options in Cardiovascular Medicine·Liesl J ZühlkeJonathan Carapetis
Aug 26, 2017·Archives of Disease in Childhood·Chris CurryNeil Kennedy
Feb 2, 2018·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 2, 2019·Circulation. Cardiovascular Imaging·Maria Carmo P NunesAndrea Z Beaton
Feb 2, 2019·Circulation. Cardiovascular Imaging·Chris T Longenecker
Sep 3, 2017·Echo Research and Practice·L D HunterP G Herbst
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Aug 28, 2016·Current Cardiology Reports·Bethel Woldu, Gerald S Bloomfield
Aug 24, 2017·The New England Journal of Medicine·David A WatkinsGregory A Roth
Feb 2, 2019·Congenital Heart Disease·Amy SanyahumbiPeter N Kazembe
Sep 26, 2020·Frontiers in Surgery·Amiliana M Soesanto, Luh Oliva Saraswati Suastika
Dec 6, 2017·Circulation·Mohammed R Essop, Bongani M Mayosi
Dec 12, 2018·International Journal of Epidemiology·Mayowa O OwolabiUNKNOWN as members of the CVD Working Group of the H3Africa Consortium
Mar 21, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Matheus Tozatto Baptista Coelho LealMaria Carmo Pereira Nunes
Apr 4, 2019·Pediatric Rheumatology Online Journal·Fortunata CondemiGianfranco De Maio
Jul 5, 2018·BMC Cardiovascular Disorders·John MusukuLiesl J Zühlke
Jun 21, 2019·Cardiology in the Young·Jennifer H KleinCraig Sable
Mar 17, 2020·Hypertension·Onoja M AkpaUNKNOWN as members of the CVD Working Group of the H3Africa Consortium
Oct 20, 2020·Circulation·Raman Krishna KumarUNKNOWN American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovasc
Aug 18, 2020·Tropical Medicine & International Health : TM & IH·Esin NkereuwemFidelia Bode-Thomas
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 7, 2021·Open Heart·Nikesh Raj ShresthaThomas Pilgrim
Aug 24, 2021·Expert Review of Cardiovascular Therapy·Sarah R de LoizagaMaria Carmo Pereira Nunes
Sep 18, 2021·Journal of the American Heart Association·Bruno R NascimentoUNKNOWN Programa de Rastreamento da Valvopatia Reumática (PROVAR) Investigators [Link]
Nov 13, 2021·The New England Journal of Medicine·Andrea BeatonAndrew C Steer

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