The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis

The Journal of Clinical Endocrinology and Metabolism
Annamaria ColaoGaetano Lombardi

Abstract

Partial GH deficiency (GHD) in adults is poorly studied. The objective of the study was to investigate the natural history and clinical implications of partial GHD. This was an analytical, observational, prospective, case-control study. Twenty-seven hypopituitary patients (15 women, ages 20-60 yr) and 27 controls participated in the study. Measures included GH peak after GHRH plus arginine [(GHRH+ARG), measured by immunoradiometric assay]; IGF-I (measured after ethanol extraction) z-sd score (SDS); glucose, insulin, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride levels; and common carotid arteries intima-media thickness (IMT) measured periodically. At study entry, partial GHD patients had significantly lower IGF-I and HDL-cholesterol levels and homeostasis model assessment index than controls. During the 60 months of median follow-up, 11 patients had severe GHD (40.7%), seven normalized their GH response (25.9%), and nine showed persistently partial GHD (33.3%). Patients with developed severe GHD at baseline had similar age and body mass index and lower GH peak (11.5 +/- 1.8 vs. 14.3 +/- 1.5 and 12.8 +/- 1.1 microg/liter, P = 0.008) and IGF-I SDS (-0.88 +/- 0.48 vs. 0.15 +/- 0.58 and -0.42 +/- 0...Continue Reading

Citations

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