The natural logarithm of zinc-α2-glycoprotein/HOMA-IR is a better predictor of insulin sensitivity than the product of triglycerides and glucose and the other lipid ratios

Cytokine
Chunmei QuZerong Liang

Abstract

The euglycemic-hyperinsulinemic clamp (EHC) is not available in most clinical settings and is costly, time consuming and invasive, and requires trained staff. Therefore, an accessible and inexpensive test to identify insulin resistance (IR) is needed. The aim of this study is to assess whether zinc-α2-glycoprotein (ZAG) index [Ln ZAG/homeostasis model assessment of IR (HOMA-IR)] is a better surrogate index for estimating IR or metabolic syndrome (MetS) compared with other surrogate indices. We performed a population-based cross-sectional study. Two hundred healthy subjects, 102 polycystic ovary syndrome (PCOS) patients, 97 newly diagnosed type 2 diabetes mellitus (nT2DM) and 84 impaired glucose tolerance (IGT) subjects were enrolled. The EHC was performed to identify IR. Circulating ZAG and adiponectin levels were determined by ELISA. The ZAG index was significantly lower in participants with IR including IGT, nT2DM and PCOS than in those without IR. In addition, subjects with MetS had lower ZAG indices and higher the product of fasting triglycerides and glucose (TyG) indices than those without MetS. The ZAG index showed a significantly stronger association with M values than the other surrogate indices, whereas the TyG index s...Continue Reading

References

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Citations

Oct 12, 2018·Diabetes/metabolism Research and Reviews·Qiao MiLing Li
May 8, 2020·Reviews in Endocrine & Metabolic Disorders·Harriet M PearseyThomas E Yates
Jul 15, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xin-Hua XiaoJiang-Hua Liu
Apr 1, 2019·Biological Trace Element Research·Juliana Soares SeveroDilina do Nascimento Marreiro
Apr 8, 2020·International Journal of Endocrinology·Adriana Sánchez-GarcíaJosé Gerardo González-González
Mar 30, 2017·International Journal of Endocrinology·Lingling XuFengying Gong
Nov 27, 2020·Frontiers in Cardiovascular Medicine·Alexander E BerezinMichael Lichtenauer
Oct 1, 2021·Archives of Endocrinology and Metabolism·Júlia Rabelo Santos FerreiraLuciane Bresciani Salaroli
Oct 16, 2021·Experimental and Therapeutic Medicine·Daniela GrădinaruRucsandra Dănciulescu Miulescu

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