Abstract
The euglycemic-hyperinsulinemic clamp (EHC) is not available in most clinical settings and is costly, time consuming and invasive, and requires trained staff. Therefore, an accessible and inexpensive test to identify insulin resistance (IR) is needed. The aim of this study is to assess whether zinc-α2-glycoprotein (ZAG) index [Ln ZAG/homeostasis model assessment of IR (HOMA-IR)] is a better surrogate index for estimating IR or metabolic syndrome (MetS) compared with other surrogate indices. We performed a population-based cross-sectional study. Two hundred healthy subjects, 102 polycystic ovary syndrome (PCOS) patients, 97 newly diagnosed type 2 diabetes mellitus (nT2DM) and 84 impaired glucose tolerance (IGT) subjects were enrolled. The EHC was performed to identify IR. Circulating ZAG and adiponectin levels were determined by ELISA. The ZAG index was significantly lower in participants with IR including IGT, nT2DM and PCOS than in those without IR. In addition, subjects with MetS had lower ZAG indices and higher the product of fasting triglycerides and glucose (TyG) indices than those without MetS. The ZAG index showed a significantly stronger association with M values than the other surrogate indices, whereas the TyG index s...Continue Reading
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jun 17, 2000·Diabetes Care·E BonoraM Muggeo
Jan 11, 2001·Diabetologia·M AlbaredaR Corcoy
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Dec 11, 2008·Metabolic Syndrome and Related Disorders·Luis E Simental-MendíaFernando Guerrero-Romero
Jul 23, 2009·The Journal of Clinical Endocrinology and Metabolism·David M SelvaRafael Simó
Jan 23, 2010·Cancer Causes & Control : CCC·Niyati ParekhGrace L Lu-Yao
Apr 3, 2010·Diabetologia·R A DeFronzo
May 21, 2010·The Journal of Clinical Endocrinology and Metabolism·Fernando Guerrero-RomeroMartha Rodríguez-Morán
Jun 2, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C BingP Trayhurn
Aug 11, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S T Russell, M J Tisdale
Sep 22, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S T Russell, M J Tisdale
Oct 15, 2010·American Journal of Physiology. Endocrinology and Metabolism·Ranganath MuniyappaAnura V Kurpad
Jan 10, 2012·Biochimica Et Biophysica Acta·Steven Thomas Russell, Michael John Tisdale
Aug 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Andrew A ButlerPeter J Havel
Nov 28, 2012·The Journal of Clinical Endocrinology and Metabolism·Wenjing HuGangyi Yang
Dec 12, 2012·Diabetes Care·Veeradej PisprasertW Timothy Garvey
Jan 1, 2013·Diabetes Care·Mengliu YangGangyi Yang
Nov 29, 2013·Journal of Internal Medicine·Y JiaL Li
Citations
Oct 12, 2018·Diabetes/metabolism Research and Reviews·Qiao MiLing Li
Mar 29, 2019·Endocrine Journal·Siyuan ZhengFang Wang
May 8, 2020·Reviews in Endocrine & Metabolic Disorders·Harriet M PearseyThomas E Yates
Jul 15, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Xin-Hua XiaoJiang-Hua Liu
Apr 1, 2019·Biological Trace Element Research·Juliana Soares SeveroDilina do Nascimento Marreiro
Apr 8, 2020·International Journal of Endocrinology·Adriana Sánchez-GarcíaJosé Gerardo González-González
Mar 30, 2017·International Journal of Endocrinology·Lingling XuFengying Gong
Apr 16, 2019·Frontiers in Endocrinology·Meijuan LiuFengying Gong
Jan 7, 2021·International Journal of Clinical Practice·Zahra NamkhahMohammad Javad Hosseinzadeh-Attar
Nov 27, 2020·Frontiers in Cardiovascular Medicine·Alexander E BerezinMichael Lichtenauer
May 11, 2021·Frontiers in Neurology·Zongyi HouYongjun Wang
Jun 4, 2021·Journal of Food Biochemistry·Yang XuLin Xie
Jun 29, 2021·Frontiers in Chemistry·Yang ZhaoXiang Fang
Jul 3, 2021·Nutrients·Michalina BanaszakJuliusz Przysławski
Oct 1, 2021·Archives of Endocrinology and Metabolism·Júlia Rabelo Santos FerreiraLuciane Bresciani Salaroli
Oct 16, 2021·Experimental and Therapeutic Medicine·Daniela GrădinaruRucsandra Dănciulescu Miulescu