The natural outcome of melamine-induced bladder stones with bladder epithelial hyperplasia after the withdrawal of melamine in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Shu-Ting RenYi-Na Jiang

Abstract

The natural outcome of melamine-induced bladder stones (cystoliths) with bladder epithelial hyperplasia (BEH) after melamine withdrawn is unclear. Using an ideal dual-model system, three experiments were conducted in BALB/c mice. Each experiment included a control, model 1 and model 2 groups. The mice were fed a regular diet in controls or a 9373 ppm melamine diet in models, and the first day was designated as dosing day 1. The melamine diet was then replaced by the regular diet in the model 2 groups, and the first day was designated as post-dosing day 1. On dosing days 12, 35 and 49, the incidence of cystoliths and diffusely active BEH was 8/8 in the mice of three model 1 groups. On post-dosing days 1, 4 and 8, in the mice of three model 2 groups, the incidence of cystoliths was 2/8, 0/8 and 1/8, respectively, and the progressive regression of BEH was observed. In conclusion, both the stones and BEH have the natural property of rapid development and rapid regression, and melamine withdrawn plays a key role in the stone dissolution-discharge necessary for BEH regression. BEH may be reversible after the discharge of the stones. The conventionally conservative therapy is thus reasonable.

References

Dec 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R W MastM A Friedman
Feb 1, 1984·Toxicology and Applied Pharmacology·R L MelnickJ Huff
Oct 29, 2008·TheScientificWorldJournal·Vincent L Yang, Daniel Batlle
Dec 26, 2008·The New England Journal of Medicine·Julie R Ingelfinger
Jan 28, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ching-Wan LamPaul Kwong-Hang Tam
Jan 28, 2009·World Journal of Pediatrics : WJP·Li ZhangZheng-Yan Zhao
Feb 7, 2009·The New England Journal of Medicine·Na GuanYong Yao
Apr 14, 2009·Urology·F GrasesJ M del Valle
Feb 8, 2011·Clinics in Laboratory Medicine·Birgit Puschner, Renate Reimschuessel
Sep 21, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Fu XuShu-Ting Ren

❮ Previous
Next ❯

Citations

Nov 1, 2013·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·C Y Chu, C C Wang
Jun 5, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Chao Chun ZouLi Li Yang
Dec 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ying SunXiao-Li Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.