The naturally occurring xanthone α-mangostin induces ROS-mediated cytotoxicity in non-small scale lung cancer cells

Saudi Journal of Biological Sciences
Chunyun ZhangYifeng Shen

Abstract

Small cell lung cancer (NSCLC) accounts for 85% of total deaths globally, and recent studies indicate the increasing risks of NSCLC in China and South Asian countries. Hence, development of new therapeutics against NSCLC has been a major concern. α-Mangostin, a naturally occurring xanthone, found abundantly in pericarps of mangosteen fruit is well known for its medicinal importance. The anticancer properties of α-mangostin against several types of cancer are also well documented. But the mechanism of action of α-mangostin against lung cancer is not well understood and requires further investigation. Therefore in the present study, we explored the therapeutic potential of α-mangostin against A549 cells. Treatment of A549 cells with α-mangostin resulted in a dose-dependent loss of cell viability, while the non-malignant cells such as hPBMC and WI-38 remained unaffected. Further we observed that the ROS plays an important role in α-mangostin -induced apoptosis in A549 cells, and administration of N-acetyl cysteine significantly abrogates α-mangostin -mediated cytotoxicity in lung cancer cells. Overall, α-mangostin induces ROS-mediated cytotoxicity in NSCLC cells.

Citations

Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hong-Jun XieTashi Tsering
Mar 21, 2018·Expert Opinion on Therapeutic Patents·Guoqing ChenLiping Deng
Aug 2, 2020·AAPS PharmSciTech·Nitjawan SahatsapanPrasopchai Patrojanasophon
Apr 14, 2020·Nanotechnology, Science and Applications·Nasrul WathoniMuchtaridi Muchtaridi
Aug 20, 2021·Future Medicinal Chemistry·Tejashri Chavan, Aaron Muth

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Methods Mentioned

BETA
density gradient centrifugation
Fluorescence Activated Cell Sorter
flow cytometry

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