The nature and function of mononuclear cells on the resorbed surfaces of bone in the reversal phase during remodeling

Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft
Takanori DomonMinoru Wakita

Abstract

In a reversal phase of bone remodeling many mononuclear cells appear on the resorbed surfaces of bone with characteristic reversal lines as revealed by transmission electron microscopy (TEM). However, these mononuclear cells have been variously hypothesized or reported. The present study examined the TEM features on the resorbed surfaces of three calcified connective tissues, and aimed to clarify the nature and function of the mononuclear cells in a reversal phase. Dentine slices cultured with isolated osteoclasts, human deciduous teeth, and rat mandibles were used in this study. Specimens were fixed, decalcified, and then embedded in Epon 812, and sectioned into 0.1-microm-thick ultrathin sections. The ultrathin sections were stained with uranyl acetate and lead citrate, and then examined by TEM. Many sharply pointed collagen fibrils with striation were observed exposed on the resorbed surfaces of cultured dentine slices, but there were neither cells nor reversal lines. The same features were observed on the root dentine surfaces of human deciduous teeth. Under many mononuclear cells in a reversal phase of remodeling, reversal lines were seen on the resorbed surfaces of rat mandibles, but there were no striated collagen fibril...Continue Reading

References

Nov 10, 1978·Calcified Tissue Research·J N Heersche
Sep 1, 1991·The American Journal of Anatomy·T Domon, M Wakita
Mar 1, 1985·Journal of Biomedical Materials Research·A Boyde, S J Jones
Jan 1, 1982·Cell and Tissue Research·P Tran VanR Baron
Feb 7, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·T DomonM Wakita
Aug 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J W SMITH
Apr 1, 1965·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B PHILIPSON

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Citations

Feb 11, 2016·Histochemistry and Cell Biology·Mohamed Essameldin AbdelgawadThomas Levin Andersen
Oct 9, 2008·The International Journal of Biochemistry & Cell Biology·Victor E Arana-Chavez, Vivian Bradaschia-Correa
Jun 12, 2013·The American Journal of Pathology·Thomas L AndersenJean-Marie Delaisse
Jan 15, 2014·The American Journal of Pathology·Helene B KristensenJean-Marie Delaisse
Nov 29, 2013·Toxicologic Pathology·Ermanno Bonucci, Paola Ballanti
Mar 5, 2002·Nature·John R Hutchinson, Mariano Garcia
Apr 13, 2019·Journal of Cell Science·Dinisha Cyril PirapaharanKent Søe
Apr 15, 2008·Archives of Biochemistry and Biophysics·Koichi Matsuo, Naoko Irie

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