PMID: 3215294Dec 1, 1988Paper

The nature and properties of squirrel lens yellow pigment

Experimental Eye Research
S Zigman, T Paxhia

Abstract

The low molecular weight yellow pigment in the gray squirrel lens is confirmed to be n-acetyl-3-OH-kynurenine (NAK). This conclusion is based upon the results of studies of the compound's optical, chromatographic, and mass spectroscopic properties. The original tentative identification of this compound was reported by Van Heyningen (1971, 1973). The pigment is distributed equivalently throughout the lens. Its absorbance increases with age, but the increase is related to the growth of the lens and not to an increase in pigment concentration. The function of NAK in the squirrel lens is to enhance vision by eliminating short-wavelength light that causes scattering and chromatic aberration. The pigmented lens also protects the retina from near-UV radiation-associated damage to the photoreceptors (Collier and Zigman, 1987).

References

Jun 1, 1973·Experimental Eye Research·K SatoA Nakajima
Apr 9, 1971·Nature·R Van Heyningen
Jan 1, 1984·Current Eye Research·J Dillon
Sep 1, 1952·The Biochemical Journal·C E DALGLIESH

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Citations

Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S ZigmanN T Yu
Apr 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·R UgarteE Silva
May 3, 2005·Experimental Eye Research·Roger J W Truscott
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·M J Davies, R J Truscott
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·P J WertenW W de Jong
May 3, 2006·Genes & Development·Olena V TaranovaLarysa H Pevny
Jul 11, 1991·Photochemistry and Photobiology·C M KrishnaD Balasubramanian
Jan 1, 1994·Documenta Ophthalmologica. Advances in Ophthalmology·K R Hightower
Mar 30, 2010·Acta Ophthalmologica·Stefan LöfgrenPer G Söderberg
Nov 22, 2005·Experimental Eye Research·P G HainsR J W Truscott
Jul 26, 2002·Experimental Eye Research·Lisa M TaylorRoger J W Truscott
Oct 1, 1992·Experimental Eye Research·M Luthra, D Balasubramanian
Mar 28, 2006·Journal of Cataract and Refractive Surgery·Robert J Cionni, Julie H Tsai
Oct 1, 1995·Current Eye Research·S J GaudetG J Chader
Dec 26, 2017·Frontiers in Neural Circuits·Matthew B Toomey, Joseph C Corbo
Jun 29, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·D Balasubramanian
Dec 1, 2001·The Journal of Biological Chemistry·Santiago VazquezRoger J W Truscott
Dec 4, 2019·Investigative Ophthalmology & Visual Science·Roger J W Truscott, Michael G Friedrich
Feb 23, 2018·Experimental Eye Research·Mark Bree, Douglas Borchman

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