The nature of cell-cycle checkpoints: facts and fallacies.

Journal of Biology
Alexey Khodjakov, Conly L Rieder

Abstract

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.

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Citations

Jan 5, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Conly L Rieder
Jul 18, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·António J Pereira, Helder Maiato
Oct 5, 2010·Nature Cell Biology·Alexey Khodjakov, Jonathon Pines
Dec 2, 2011·Molecular Biology of the Cell·William T SilkworthDaniela Cimini
Nov 16, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrea Musacchio
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Feb 11, 2011·Trends in Cell Biology·Juraj GreganDaniela Cimini
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Dec 14, 2011·Molecular Cell·Gianluca VarettiAndrea Musacchio
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Jan 15, 2017·Microbiology Spectrum·Ilkay Dörter, Michelle Momany

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Methods Mentioned

BETA
fluorescence-activated cell sorting

Related Concepts

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Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.