The nature of prostaglandin-like substances released from guinea-pig lung in anaphylaxis

European Journal of Pharmacology
D J CrutchleyJ P Seale

Abstract

The pulmonary inactivation of infused prostaglandin E2 by isolated perfused lungs of guinea pigs was inhibited with di-4 phloretin phosphate (DPP) without significantly altering the antigen-induced release of prostaglandin-like substances or histamine. Similar data were obtained when the lungs were perfused in a reverse direction. These results suggest that parent prostaglandins are not major constituents of the prostaglandin-like substances released from guinea-pig lungs during anaphylaxis.

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Apr 1, 1976·Prostaglandins·M W Anderson, T E Eling
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jul 1, 1975·British Journal of Pharmacology·D J Crutchley, P J Piper
Apr 8, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·D P EvansD S Thomson
Oct 1, 1974·British Journal of Pharmacology·D J Crutchley, P J Piper
Feb 14, 1970·Nature·P J PiperJ H Wyllie

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Citations

Jan 1, 1984·The American Journal of Emergency Medicine·J T Flynn
Oct 1, 1981·Australian and New Zealand Journal of Medicine·J P Seale
Oct 1, 1980·British Journal of Pharmacology·T M FitzpatrickP W Ramwell

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.