The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation

PloS One
Beata Filipek-GórniokLena Kjellén

Abstract

Heparan sulfate (HS) proteoglycans are ubiquitous components of the extracellular matrix and plasma membrane of metazoans. The sulfation pattern of the HS glycosaminoglycan chain is characteristic for each tissue and changes during development. The glucosaminyl N-deacetylase/N-sulfotransferase (NDST) enzymes catalyze N-deacetylation and N-sulfation during HS biosynthesis and have a key role in designing the sulfation pattern. We here report on the presence of five NDST genes in zebrafish. Zebrafish ndst1a, ndst1b, ndst2a and ndst2b represent duplicated mammalian orthologues of NDST1 and NDST2 that arose through teleost specific genome duplication. Interestingly, the single zebrafish orthologue ndst3, is equally similar to tetrapod Ndst3 and Ndst4. It is likely that a local duplication in the common ancestor of lobe-finned fish and tetrapods gave rise to these two genes. All zebrafish Ndst genes showed distinct but partially overlapping expression patterns during embryonic development. Morpholino knockdown of ndst1b resulted in delayed development, craniofacial cartilage abnormalities, shortened body and pectoral fin length, resembling some of the features of the Ndst1 mouse knockout.

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Citations

Nov 16, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lin WangYongyong Shi
Dec 24, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Srishti ManochaWalid D Fakhouri
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Feb 28, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sebastian KeilFranziska Knopf

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Datasets Mentioned

BETA
AAVX01040746.1
AAVX01090192.1

Methods Mentioned

BETA
PCR
antisense oligonucleotides
in vitro transcription
transgenic

Software Mentioned

BLAST
SEQBOOT
PROTDIST
Ensembl
Phylip
CONSENSE

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