The need for better preventative strategies for inflammatory bowel disease patients at risk of herpes zoster virus

Internal Medicine Journal
William A ByeAlissa J Walsh

Abstract

Immunosuppressed inflammatory bowel disease (IBD) patients have an increased risk of herpes zoster virus (HZV) infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in others. To describe characteristics of IBD patients suffering HZV to enable implementation of risk mitigation strategies for those at highest risk. Gastroenterologists completed a proforma for IBD patients who experienced HZV infection: IBD phenotype, details of HZV infection, immunosuppression and any change to treatment upon diagnosis of HZV. A total of 30 cases was identified: Crohn disease (CD) (n = 25) and ulcerative colitis (n = 5). In total, 80% (20/25) of the CD patients had penetrating, stricturing or perianal disease. Time from commencement of immunosuppression to HZV infection was highly variable (range: 3 months to over 10 years). A total of 90% (27/30) of patients was on at least one immunosuppressive therapy; of those, one-third was on monotherapy (9/27) and two-thirds (18/27) on dual therapy. A total of 89% (24/27) of immunosupressed patients was on a thiopurine (monotherapy; 6/27) or in combination (18/27). Complications of HZV occurred in 27% (8/30) of patients. Our seri...Continue Reading

References

Oct 15, 1989·Annals of Internal Medicine·D H PresentB I Korelitz
Sep 1, 1982·Medicine·M W RagozzinoH O Perry
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K Schmader
Nov 6, 2001·Epidemiology and Infection·M BrissonG De Serres
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sita GourishankarJutta K Preiksaitis
Jan 15, 2004·The Lancet Infectious Diseases·Sara L Thomas, Andrew J Hall
Oct 9, 2004·Inflammatory Bowel Diseases·Bruce E SandsWalter Orenstein
Apr 7, 2005·Nature Medicine·Stanley A Plotkin
Oct 3, 2006·Inflammatory Bowel Diseases·Richard B GearryMurray L Barclay
Dec 13, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gauree GuptaJames D Lewis
Feb 15, 2007·Human Vaccines·Michael N Oxman
May 2, 2009·Inflammatory Bowel Diseases·Tanya M Monaghan, Bernard Norton
Jun 18, 2009·The American Journal of Gastroenterology·Josh MarehbianWilliam J Sandborn
Jan 12, 2011·Mayo Clinic Proceedings·Barbara P YawnPatricia Saddier
May 28, 2011·Inflammatory Bowel Diseases·Garret CullenAdam S Cheifetz
Mar 22, 2012·Inflammatory Bowel Diseases·Garret CullenAdam S Cheifetz
Dec 18, 2012·Alimentary Pharmacology & Therapeutics·M D LongM D Kappelman
Aug 1, 2013·World Journal of Gastroenterology : WJG·Györgyi MűzesFerenc Sipos
Feb 7, 2014·The Cochrane Database of Systematic Reviews·Ning ChenLi He
Mar 13, 2014·Journal of Crohn's & Colitis·J F RahierUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jul 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnaud M DidierlaurentSandra Morel
Nov 6, 2014·The Journal of Infectious Diseases·Elchonon M BerkowitzUNKNOWN Zoster-015 HZ/su Study Group
Apr 29, 2015·The New England Journal of Medicine·Himal LalUNKNOWN ZOE-50 Study Group

❮ Previous
Next ❯

Citations

Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrienne P GilkesAmanda M Burkhardt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Gastroenterology
James D LewisBrian L Strom
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Gauree GuptaJames D Lewis
© 2022 Meta ULC. All rights reserved