PMID: 6109453Feb 1, 1981Paper

The need for continuous use of antiparkinsonian medication with chronic schizophrenic patients receiving long-term neuroleptic therapy

The American Journal of Psychiatry
N ManosJ Logothetis

Abstract

In this double-blind six-week study, 98 chronic schizophrenic patients receiving long-term neuroleptic treatment and trihexyphenidyl were switched to either placebo or study trihexyphenidyl. Fifty-one (68%) of the 75 patients given placebo versus 1 of the 23 patients who continued on active trihexyphenidyl developed severe worsening of extrapyramidal signs, necessitating early termination from the study. Twenty-one (28%) of the placebo patients versus 2 (8.7%) of the trihexyphenidyl patients developed less severe worsening. Furthermore, 50 (66.6%) of the placebo patients but only 2 (8.7%) of the trihexyphenidyl patients had psychotic or other severe physical symptoms related to withdrawal of prestudy antiparkinsonian medication. The authors conclude that these data support the need for continuous use of antiparkinsonian medication in the long-term neuroleptic therapy of chronic schizophrenic patients.

Citations

Aug 1, 1991·Journal of Clinical Pharmacology·M R Lavin, A Rifkin
Nov 1, 1984·Comprehensive Psychiatry·M H el-Defrawi, T J Craig
Jun 1, 1986·The Australian and New Zealand Journal of Psychiatry·G Caradoc-DaviesP E Mullen
Jun 2, 2012·Journal of Psychopharmacology·Julie Eve DesmaraisHoward C Margolese
Jul 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·A RifkinR Munne
Sep 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·W GreilE Rüther
Aug 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·R H Mindham
Mar 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·T R Barnes
Oct 1, 1985·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·R Yassa
Nov 1, 1985·Drug Intelligence & Clinical Pharmacy·S R BateyH H Fetner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here