The Need for Restructuring the Disordered Science of Amorphous Drug Formulations

Pharmaceutical Research
Khadijah EduengChristel A S Bergström

Abstract

The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses...Continue Reading

References

Oct 1, 1969·The Journal of Pharmacy and Pharmacology·T R Bates
Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Dec 1, 1969·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
May 1, 1969·Journal of Pharmaceutical Sciences·A P SimonelliW I Higuchi
Nov 1, 1966·Journal of Pharmaceutical Sciences·M Mayersohn, M Gibaldi
Aug 1, 1984·Journal of Pharmaceutical Sciences·S A Varia, V J Stella
Jun 9, 1999·Molecular Cell·H WangB M Forman
Jun 28, 2000·Pharmaceutical Research·B C Hancock, M Parks
Aug 16, 2001·The Journal of Biological Chemistry·X FuE G Lund
May 31, 2002·Journal of Medicinal Chemistry·Daniel F VeberKenneth D Kopple
Nov 13, 2004·Journal of Medicinal Chemistry·Jing J LuPhilip S Burton
Oct 13, 2007·Journal of Medicinal Chemistry·Christel A S BergströmIna Hubatsch
Nov 1, 2007·Nature Reviews. Drug Discovery·Paul D Leeson, Brian Springthorpe
Apr 10, 2008·Journal of Medicinal Chemistry·Carola M WassvikChristel A S Bergström
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Morten AllesøJaakko Aaltonen
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sandrien JanssensGuy Van den Mooter
Jul 14, 2010·Journal of Pharmaceutical Sciences·Jared A BairdLynne S Taylor
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Thorsteinn Loftsson, Marcus E Brewster
Feb 4, 2011·Journal of Pharmaceutical Sciences·Parijat KanaujiaReginald B H Tan
May 25, 2011·Journal of Pharmaceutical Sciences·David E AlonzoLynne S Taylor
Jul 19, 2011·Colloids and Surfaces. B, Biointerfaces·M KakranL Li
Jul 26, 2011·International Journal of Pharmaceutics·Indrajit GhoshSudha Vippagunta
Aug 2, 2011·International Journal of Pharmaceutics·Hisham Al-ObaidiGraham Buckton
Aug 30, 2011·International Journal of Pharmaceutics·Jingjun HuangNavnit H Shah
Oct 1, 2011·Nature Reviews. Drug Discovery·Paul D Leeson, Stephen A St-Gallay
Dec 6, 2011·Archives of Pharmacal Research·Ying ChenHong Liu

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Citations

Aug 3, 2018·The Journal of Pharmacy and Pharmacology·Felix DitzingerMartin Kuentz
Jul 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khadijah EduengChristel A S Bergström
Dec 22, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Esther S BochmannBernd Liepold
Nov 16, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Afroditi KapouraniPanagiotis Barmpalexis
Feb 9, 2020·International Journal of Pharmaceutics·Konstantinos KatopodisPanagiotis Barmpalexis
Jun 14, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ya-Wei LiNian-Qiu Shi
Nov 26, 2019·ACS Omega·Lindsay M Johnson, Marc A Hillmyer
Jan 13, 2018·Molecular Pharmaceutics·Benjamin SchamméGérard Coquerel
Jan 11, 2018·Bioconjugate Chemistry·Jeffrey M TingTheresa M Reineke
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Al-Shymaa Y MohammedAhmed I A Abd El-Mageed

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Methods Mentioned

BETA
infrared
nuclear magnetic resonance
NMR
differential scanning calorimetry
confocal

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