The need for treatment against human parechoviruses: how, why and when?

Expert Review of Anti-infective Therapy
J G WildenbeestK C Wolthers

Abstract

Since 1999, human parechoviruses (HPeVs) have been classified as a separate group in the large and expanding family of Picornaviridae. In contrast to the well-established group of the human enteroviruses (HEVs), HPeVs have long been considered as irrelevant and have only been associated with mild disease manifestations in children. The identification of HPeV-3 in 2004 and its association with neonatal sepsis, refocused attention on this neglected group of viruses. Clinically HPeV infections may mimic HEV infections and are increasingly recognized as viral causes of sepsis-like illness and CNS infections in young children. Therapy is not available against HPeVs or HEVs. In this article, we will demonstrate that therapy against this group of picornaviruses is urgently needed and we will review the current knowledge of treatment options as well as the current developments in antiviral therapy against picornaviruses in the scope of treatment possibilities against HPeVs.

References

Jul 1, 1992·Journal of Clinical Immunology·S A MisbahH M Chapel
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Timo HyypiäGlyn Stanway
Jan 1, 1989·Scandinavian Journal of Infectious Diseases·M KoskiniemiK Linnavuori
Dec 1, 1989·Journal of Medical Virology·J P FigueroaB Hull
May 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M J AbzugHarley A Rotbart
Feb 1, 1995·The Pediatric Infectious Disease Journal·B A JantauschW J Rodriguez
Jan 1, 1993·Scandinavian Journal of Infectious Diseases·A Ehrnst, M Eriksson
Jan 1, 1996·Scandinavian Journal of Infectious Diseases·A Ehrnst, M Eriksson
Jan 1, 1996·Archives of Virology·David P SchnurrJ Connor
Aug 22, 1997·The Journal of Biological Chemistry·T PulliTimo Hyypiä
May 8, 1998·American Journal of Perinatology·C C ChiouB Hwang
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Joki-Korpela, Timo Hyypiä
Nov 20, 1998·The Journal of General Virology·F GhaziGlyn Stanway
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·Daniel C PevearJ M Groarke
Feb 2, 2000·Reviews in Medical Virology·G StanwayTimo Hyypiä
Jun 22, 2000·The Journal of General Virology·P Joki-KorpelaTimo Hyypiä
Feb 13, 2001·Journal of Virology·P Joki-KorpelaTimo Hyypiä
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J M GalamaC M Weemaes
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Harley A RotbartPleconaril Treatment Registry Group
Sep 18, 2001·Journal of Virology·Y BoonyakiatGlyn Stanway
Dec 26, 2001·Antiviral Research·Harley A Rotbart
Nov 20, 2002·Journal of Virology·Abdolrahman S NateriGlyn Stanway
Apr 12, 2003·The Pediatric Infectious Disease Journal·Mark J AbzugNational Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Jun 13, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frederick G HaydenPleconaril Respiratory Infection Study Group
Jul 15, 2003·Journal of Virology·Camilla KrogerusKurt Bienz
Aug 15, 2003·The Journal of General Virology·Heli HarvalaTimo Hyypiä
Jan 1, 1961·Archiv für die gesamte Virusforschung·R WIGAND, A B SABIN
Feb 11, 2004·The Journal of General Virology·Miyabi ItoKenji Sakae
Dec 2, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A D B Webster
Feb 12, 2005·Emerging Infectious Diseases·Guy BoivinFrançois D Boucher
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberley S M BenschopK C Wolthers
Mar 3, 2006·The Pediatric Infectious Disease Journal·Alison C RentzCarrie L Byington
May 19, 2006·Emerging Infectious Diseases·Yacine Abed, Guy Boivin
Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Dec 21, 2006·Emerging Infectious Diseases·Kimberley S M BenschopK C Wolthers
Feb 22, 2007·Journal of Medical Virology·Sisko TauriainenHeikki Hyöty
Feb 24, 2007·European Journal of Pediatrics·Katerina KatsibardiFotini Tzortzatou-Stathopoulou

Citations

Aug 13, 2015·Viruses·Lonneke van der LindenFrank J M van Kuppeveld
Oct 21, 2015·Emerging Infectious Diseases·Yuta AizawaAkihiko Saitoh
Sep 15, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Muhammad Masroor AlamSyed Sohail Zahoor Zaidi
Apr 3, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Susanna EspositoHubert G M Niesters
Jul 17, 2012·Journal of Virological Methods·R P MinnaarKimberley S M Benschop
Aug 31, 2016·Epidemiology and Infection·K WatanabeT Tazawa
Jun 21, 2017·The Journal of General Virology·Maria AnastasinaSarah J Butcher
Jul 11, 2015·Journal of Virology·Shabih ShakeelSarah J Butcher
Nov 2, 2018·The Pediatric Infectious Disease Journal·Eveliina KarelehtoK C Wolthers
Nov 20, 2019·Viruses·Adithya SridharK C Wolthers
Jul 18, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Karageorgou IouliaMentis Andreas
Mar 1, 2016·Uirusu·Yuta Aizawa, Akihiko Saitoh
May 3, 2018·The Medical Journal of Australia·Philip N BrittonAllen C Cheng

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.