The Nefarious Nexus of Noncoding RNAs in Cancer

International Journal of Molecular Sciences
Eleni AnastasiadouFrank J Slack

Abstract

The past decade has witnessed enormous progress, and has seen the noncoding RNAs (ncRNAs) turn from the so-called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer.

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Citations

Oct 4, 2019·Oncology Letters·Chuan Fang, Yadong Li
Oct 26, 2018·Hypertension·Gengze WuChunyu Zeng
Apr 11, 2019·International Journal of Molecular Sciences·Stéphane FlamantAnnelise Bennaceur-Griscelli
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Jun 2, 2021·NPJ Breast Cancer·Zhenbo TuAntoine E Karnoub

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Methods Mentioned

BETA
Adenylation
exome sequencing
immunoprecipitation
ubiquitination
acetylation
immunoprecipitation assay

Software Mentioned

CircBase
Circ2Traits
Drosha
circRNADb

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