PMID: 7541597Jan 1, 1995Paper

The negative component in schizophrenia

Acta Psychiatrica Scandinavica. Supplementum
H J Möller

Abstract

Many conflicts in the literature about negative symptoms arise because different authors use different definitions of negative symptoms. If narrow definitions are used, it appears that drugs have little effect against negative symptoms, although those who use broader definitions tend to conclude that negative symptoms do respond to drugs. Another complication is that negative symptoms may be secondary to other causes, such as psychotic symptoms, the side effects of drugs, depression and understimulation as a result of hospitalisation. Attempting to measure drug effects on negative symptoms can be complicated by such factors as different co-medication in the test and control groups and different pharmacological profiles of test and standard drugs, in particular in terms of extrapyramidal side effects or antidepressant effects. Several approaches to dissecting the direct effect of drugs from their indirect effects on negative symptoms have included analyses of covariance, regression analyses and path analyses. Applying path analysis to the data from the North American clinical trial of risperidone suggests that a significant component of the advantageous effect of risperidone on negative symptoms, compared with haloperidol, is du...Continue Reading

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Citations

Jan 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G BondolfiH Dufour
Oct 5, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·S MoritzM Krausz
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D J King
Jul 17, 2007·European Archives of Psychiatry and Clinical Neuroscience·Michael RiedelHans-Jürgen Möller
Jul 3, 2008·European Archives of Psychiatry and Clinical Neuroscience·Hans-Jürgen Möller
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H J Möller
Oct 19, 2001·CNS Drug Reviews·H Silver

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