PMID: 4901476Aug 1, 1969Paper

The negative control mechanism for E. coli DNA replication

Proceedings of the National Academy of Sciences of the United States of America
B H RosenbergG Ungers

Abstract

Evidence is presented to show that the initiation of DNA replication in E. coli 555-7 requires synthesis of a protein whose production is correlated with total protein synthesis. Once replication is initiated, however, reinitiation will occur if all further protein synthesis is prevented; a small amount of protein synthesis is sufficient to prevent this unregulated reinitiation. This shows that the initiation of DNA replication is under negative control. A mechanism for the control of DNA replication is proposed; in this mechanism a replication repressor is synthesized periodically, while an antirepressor protein is synthesized continuously. Derepression of initiation results after sufficient accumulation of the antirepressor protein, and repression is re-established by repressor synthesis after the initiation of replication.

References

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Oct 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·H YOSHIKAWAN SUEOKA

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Citations

Jan 10, 1979·Molecular & General Genetics : MGG·R Tippe-SchindlerW Messer
Aug 7, 1979·Journal of Theoretical Biology·J Tyson, W Sachsenmaier
Jan 1, 1983·Bio Systems·L AlberghinaG Bortolan
Apr 28, 1972·Journal of Molecular Biology·H Weintraub, H Holtzer
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·W E Masker, H Eberle
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·S Blau, J Mordoh
Aug 7, 1982·Journal of Theoretical Biology·A Wheals, B Silverman
Mar 1, 1975·Journal of Theoretical Biology·P A FantesA E Wheals
Apr 16, 1973·Biochemical and Biophysical Research Communications·W Goebel
Jan 3, 1974·European Journal of Biochemistry·W Goebel
Feb 1, 1978·Journal of Bacteriology·F C Kung, D A Glaser
Apr 1, 1973·Journal of Virology·M S HorwitzS G Baum
Jul 1, 1975·Journal of Bacteriology·B Engberg, K Nordström

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