PMID: 11902820Mar 21, 2002Paper

The NeiI polymorphism in the cyclin D1 gene and sporadic primary hyperparathyroidism

Journal of Internal Medicine
P CorreaT Carling

Abstract

The cell cycle regulator cyclin D1 plays an important role in parathyroid tumourigenesis. The NciI polymorphism in exon 4 has recently been associated with early onset of hereditary nonpolyposis colorectal cancer and is a prognostic indicator of nonsmall cell lung cancer and squamous cell carcinomas. Furthermore, a limited study of 28 primary hyperparathyroidism (pHPT) patients displayed a tendency of NciI influence on HPT development. We hypothesized that the NciI polymorphism may relate to a risk of developing pHPT. We genotyped 182 patients with sporadic pHPT and matched controls for the cyclin D1 polymorphism. A total of 88 pHPT patients and controls were recruited via a health-screening. The frequency distribution of the NciI genotypes NN, Ni, and ii were in pHPT patients and controls 22, 44 and 34%, and 26, 49 and 25%, respectively. The calculated allele frequencies were A = 0.56; G = 0.44 in cases and A = 0.49; G = 0.51 in controls. The frequency distributions did not differ comparing cases and controls when subgrouped after age and menopausal status. The NciI genotypes were not significantly associated with age of the individuals, serum (s)-calcium, s-parathyroid hormone (PTH), bone mineral density (BMD) or parathyroid ...Continue Reading

References

Oct 11, 1991·Nucleic Acids Research·J Heighway
Apr 11, 1991·Nature·T MotokuraA Arnold
Jan 1, 1991·Cold Spring Harbor Symposia on Quantitative Biology·A ArnoldH G Kim
Dec 1, 1995·Nature Medicine·T CarlingH Melhus
Jun 13, 1998·Molecular Pathology : MP·R Donnellan, R Chetty
Mar 8, 2000·Frontiers in Bioscience : a Journal and Virtual Library·S M Mallya, A Arnold
Jun 28, 2000·European Journal of Endocrinology·S JordanA B Grossman
Feb 13, 2001·Trends in Endocrinology and Metabolism : TEM·T Carling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.