The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia

Developmental Neuroscience
H J C BonestrooC J Heijnen

Abstract

Neonatal encephalopathy due to perinatal hypoxia-ischemia (HI) is a severe condition, and current treatment options are limited. Expression of endogenous osteopontin (OPN), a multifunction glycoprotein, is strongly upregulated in the brain after neonatal HI. Intracerebrally administered OPN has been shown to be neuroprotective following experimental neonatal HI and adult stroke. In the present study, we determined whether intranasal, intraperitoneal or intracerebral treatment with a smaller TAT-OPN peptide is neuroprotective in neonatal mice with HI brain damage. The TAT-OPN peptide exerts bioactivity as it was as potent as full-length OPN in inducing cell adhesion in an in vitro adhesion assay. Intranasal administration of TAT-OPN peptide immediately after HI (T0) or in a repetitive treatment schedule of T0, 3 h, day (D) 1, 2 and 3 after HI did not protect cerebral gray or white matter after HI. Intraperitoneal TAT-OPN treatment at T0 or in two extended treatment schedules (D5, 7, 9, 11, 13, 15 after HI or T0, D1, 3, 5, 7, 9, 11, 13 and 15 after HI) did not result in neuroprotection either. Moreover, no functional improvement (cylinder rearing test and adhesive removal task) was observed following TAT-OPN treatment in any of t...Continue Reading

Citations

Sep 22, 2015·International Journal of Molecular Sciences·Brandon J DixonJohn H Zhang
Dec 16, 2016·International Journal of Molecular Sciences·Mingyi ZhaoXiao-Kang Li
Jul 19, 2017·Antioxidants & Redox Signaling·David Labrousse-AriasMaría J Calzada
Sep 11, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rulan JiangBo Lönnerdal
Jul 14, 2020·Journal of Cellular and Molecular Medicine·Yunxiang ZhouAnwen Shao
Jan 20, 2021·Physiological Research·A FrajewickiV Riljak

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