The neonatal Fc receptor is a pan-echovirus receptor.

Proceedings of the National Academy of Sciences of the United States of America
Stefanie MoroskyCarolyn B Coyne

Abstract

Echoviruses are amongst the most common causative agents of aseptic meningitis worldwide and are particularly devastating in the neonatal population, where they are associated with severe hepatitis, neurological disease, including meningitis and encephalitis, and even death. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (β2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to β2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells. We also show that expression of human, but not mouse, FcRn renders nonpermissive human and mouse cells sensitive to echovirus infection and that the extracellular domain of human FcRn directly binds echovirus particles and neutralizes infection. Lastly, we show that neonatal mice expressing human FcRn are more susceptible to echovirus infection by the enteral route. Our findings thus identify FcRn as a pan-echovirus receptor, which may explain the enhanced susceptibility of neonates to echovirus infections.

References

Mar 27, 1992·Science·J M BergelsonR W Finberg
Nov 23, 1990·Journal of Chromatography·G Stöcker, D C Fischer
Jan 12, 1989·Nature·N E Simister, K E Mostov
Aug 1, 1988·The Journal of Infectious Diseases·J L NielsenG D Hankins
Nov 1, 1972·The Journal of Clinical Investigation·E A Jones, T A Waldmann
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·J M BergelsonR W Finberg
Mar 12, 1999·The Journal of General Virology·T WardJ W Almond
Oct 8, 1999·The Journal of Clinical Investigation·B L DickinsonW I Lencer
Feb 5, 2003·The Journal of Experimental Medicine·Chaity ChaudhuryClark L Anderson
Apr 12, 2006·Biochemistry·Chaity ChaudhuryClark L Anderson
Apr 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S C SweetJ C Magee
Aug 19, 2007·Nature Reviews. Immunology·Derry C Roopenian, Shreeram Akilesh
Mar 24, 2009·Seminars in Fetal & Neonatal Medicine·Marc Tebruegge, Nigel Curtis
Dec 17, 2009·Methods in Molecular Biology·Derry C RoopenianThomas J Sproule
Apr 12, 2013·BMJ Case Reports·Cristina PedrosaDaniel Virella
Dec 18, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M TassinC Vauloup-Fellous
Feb 24, 2015·Advanced Drug Delivery Reviews·Jonathan T Sockolosky, Francis C Szoka
May 3, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michal PyzikRichard S Blumberg
May 23, 2015·Pediatric Annals·Julia C Haston, Terry C Dixon
Mar 11, 2016·Journal of Virology·Stefanie MoroskyCarolyn B Coyne
Feb 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Coyne G DrummondCarolyn B Coyne
Mar 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Michal PyzikRichard S Blumberg
Apr 14, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sari LatvalaSven Kronenberg
May 12, 2017·Cell Host & Microbe·Nitin AroraCarolyn B Coyne
May 11, 2018·American Journal of Reproductive Immunology : AJRI·Natalia A LozanoMarina F Ponzio
Mar 12, 2019·Science Advances·Charles GoodCarolyn B Coyne

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Citations

Aug 2, 2019·Future Microbiology·Xingjian WenAnchun Cheng
Nov 20, 2019·Viruses·Adithya SridharKatja C Wolthers
Jul 30, 2019·Frontiers in Immunology·Michal PyzikRichard S Blumberg
Apr 25, 2020·Frontiers in Microbiology·Anna MajerTimothy F Booth
May 24, 2019·Viruses·Alexandra I Wells, Carolyn B Coyne
Aug 9, 2020·Frontiers in Molecular Biosciences·Yang WangJing Wang
Jan 9, 2020·Nature Communications·Yuguang ZhaoDavid I Stuart
Apr 17, 2020·Journal of Virology·Helena VandesandeVarpu Marjomäki
Jun 20, 2020·Expert Opinion on Therapeutic Targets·Mira LaajalaVarpu Marjomäki
Jan 28, 2021·Viruses·Christine E Peters, Jan E Carette
Sep 9, 2020·The Journal of Allergy and Clinical Immunology·Dhavalkumar D Patel, James B Bussel

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