The nerve of ovulation-inducing factor in semen

Proceedings of the National Academy of Sciences of the United States of America
Marcelo H RattoGregg P Adams


A component in seminal fluid elicits an ovulatory response and has been discovered in every species examined thus far. The existence of an ovulation-inducing factor (OIF) in seminal plasma has broad implications and evokes questions about identity, tissue sources, mechanism of action, role among species, and clinical relevance in infertility. Most of these questions remain unanswered. The goal of this study was to determine the identity of OIF in support of the hypothesis that it is a single distinct and widely conserved entity. Seminal plasma from llamas and bulls was used as representative of induced and spontaneous ovulators, respectively. A fraction isolated from llama seminal plasma by column chromatography was identified as OIF by eliciting luteinizing hormone (LH) release and ovulation in llamas. MALDI-TOF revealed a molecular mass of 13,221 Da, and 12-23 aa sequences of OIF had homology with human, porcine, bovine, and murine sequences of β nerve growth factor (β-NGF). X-ray diffraction data were used to solve the full sequence and structure of OIF as β-NGF. Neurite development and up-regulation of trkA in phaeochromocytoma (PC(12)) cells in vitro confirmed NGF-like properties of OIF. Western blot analysis of llama and ...Continue Reading


Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L A Greene, A S Tischler
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C Ayer-LeLievreH Persson
Jul 1, 1985·Journal of Reproduction and Fertility·B X ChenG W Pan
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R H Angeletti, R A Bradshaw
Dec 5, 1994·Neuroscience Letters·G Taglialatela, J R Perez-Polo
Oct 15, 1994·Journal of Neuroscience Research·R LoyR Perez-Polo
Oct 1, 1994·Endocrinology·J C Patterson, G V Childs
Nov 1, 1994·European Journal of Biochemistry·R KolbeckY A Barde
Jan 1, 1996·Endocrinology·G A DissenS R Ojeda
Jun 5, 1999·Reviews of Reproduction·P Brown, A S McNeilly
Dec 6, 2002·Microscopy Research and Technique·Barbara BarboniNicola Bernabò
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·J Michael Bedford
Feb 1, 2005·The American Journal of Pathology·Carlos E PedrazaCarme Espinet
Apr 15, 2005·Molecular Human Reproduction·R AbirA Ao
May 13, 2005·Biology of Reproduction·Gregg P AdamsJaswant Singh
Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Marcelo H RattoGregg P Adams
Nov 14, 2006·Reproductive Biology and Endocrinology : RB&E·Marcela Julio-PieperCarmen Romero
May 14, 2010·Reproductive Biology and Endocrinology : RB&E·Marcelo H RattoGregg P Adams
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May 20, 2011·Biology of Reproduction·Valeria M TancoGregg P Adams
Jun 1, 2011·Reproductive Biology and Endocrinology : RB&E·Mauricio E SilvaMarcelo H Ratto
Jun 10, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·O A BogleG P Adams
Sep 9, 2011·Animal Reproduction Science·M SilvaM H Ratto

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