The nervous system's potential role in multiple sclerosis associated bone loss

Journal of the Neurological Sciences
Sowmya JosyulaBianca Weinstock-Guttman

Abstract

Osteoporosis is a degenerative bone disease that causes significant morbidity and mortality in multiple sclerosis (MS) patients; the pathogenesis of this disease being poorly understood in the context of MS. Osteoporosis is seen more frequently in MS patients than in healthy controls matched for age and sex. Extensively studied factors, including impaired ambulation and the use of steroids, do not appear to completely account for the phenomenon. This review summarizes common risk factors, physiologic and genetic, that may contribute to the etiology and progression of osteoporosis in MS patients as well as providing insight into nervous system control of bone metabolism and homeostasis.

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Citations

Jun 24, 2015·Acta Clinica Belgica·I Coskun BenlidayiM Demirkiran
Feb 25, 2015·BioMed Research International·Guixian DongLitao Wang

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