The network of antigen-antibody reactions in adult women with breast cancer or benign breast pathology or without breast pathology

PloS One
Tania Romo-GonzálezCarlos Larralde

Abstract

The Immunoglobulin G (IgG) antibody response to different protein antigens of the mammary ductal carcinoma by adult women affected by Breast Cancer (BC) distinguishes at least 103 proteins that differ in their molecular weights (MW). The IgG producing cell clones (nodes) coexist with each other in each individual organism and share energy resources among themselves, as well as factors that control the level of expression and Specificity of their IgG antibodies. So, it can be proposed that among them there is a Network of interconnections (links) unveiled by the antigens, which specifically react with the IgG antibodies produced by the clones. This Network possibly regulates IgG antibodies' activity and effectiveness. We describe the Network of nodes and links that exists between the different antigens and their respective IgG producing cell clones against the extracted protein antigens from the cells of the T47D Cell-Line, in 50 women with BC, 50 women with Benign Breast Pathology (BBP) and 50 women without breast pathology (H). We have found that women with BBP have the highest number of Links, followed by the H group and, lastly, the women with BC, a finding which suggests that cancer interferes with the Connectivity between ...Continue Reading

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Citations

Dec 28, 2017·Nature Reviews. Immunology·Olivera J Finn
Jun 8, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Istéfani Luciene da SilvaEnio Ferreira

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