The Network of Non-coding RNAs in Cancer Drug Resistance

Frontiers in Oncology
Fabio CorràStefano Volinia

Abstract

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption of their function through somatic mutations, genomic imprinting, transcriptional and post-transcriptional regulation, plays an ever-increasing role in cancer development. ncRNAs, including notorious microRNAs, have been thus proposed to function as tumor suppressors or oncogenes, often in a context-dependent fashion. In parallel, ncRNAs with altered expression in cancer have been reported to exert a key role in determining drug sensitivity or restoring drug responsiveness in resistant cells. Acquisition of resistance to anti-cancer drugs is a major hindrance to effective chemotherapy and is one of the most important causes of relapse and mortality in cancer patients. For these reasons, non-coding RNAs have become recent focuses as prognostic agents and modifiers of chemo-sensitivity. This review starts with a brief outline of the role of most studied non-coding RNAs in cancer and then highlights the modulation of cancer drug resistance via known ncRNAs based mechanisms. We identified from literature 388 ncRNA-drugs interactions and analyzed them using an unsupervised approach. Essentially, we performed a network analysis of the non-coding R...Continue Reading

References

Feb 17, 1998·Drugs·E A Eisenhauer, J B Vermorken
Nov 2, 2001·Nature·T ReyaI L Weissman
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
May 2, 2003·Nature Reviews. Cancer·Daniel B LongleyPatrick G Johnston
Dec 6, 2003·Science·Chang-Zheng ChenDavid P Bartel
Apr 2, 2004·Nature Reviews. Cancer·Mary Ann Jordan, Leslie Wilson
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jul 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jul 31, 2004·Science·Raffaella SordellaJeffrey Settleman
Jun 10, 2005·Nature·Jun LuTodd R Golub
Jun 21, 2005·Nature Genetics·Isaac BentwichZvi Bentwich
Sep 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amelia CimminoCarlo M Croce
Oct 26, 2005·Breast Cancer Research and Treatment·Robert I Nicholson, Stephen R Johnston
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
May 3, 2006·Biological & Pharmaceutical Bulletin·Yukihiro AkaoTomoki Naoe
May 26, 2006·Nature Reviews. Molecular Cell Biology·James A Goodrich, Jennifer F Kugel
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Song WangWei-Feng Chen
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Dec 27, 2006·The Pharmacogenomics Journal·T Wurdinger, F F Costa
Mar 14, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tito Fojo
Apr 3, 2007·Nature Genetics·Madhu S KumarTyler Jacks
May 3, 2007·JAMA : the Journal of the American Medical Association·Mark BloomstonCarlo M Croce
May 8, 2007·Molecular Cancer Therapeutics·Paul E BlowerWolfgang Sadee
Jun 15, 2007·World Journal of Gastroenterology : WJG·Hong-He ZhangNing-Min Yang
Aug 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Prasun J MishraJoseph R Bertino
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Sep 19, 2007·Cancer Research·Marilena V IorioCarlo M Croce
Sep 22, 2007·IUBMB Life·Britta Stordal, Mary Davey
Oct 19, 2007·Cancer Research·Valerie B SampsonLeslie J Krueger
Nov 17, 2007·Human Molecular Genetics·Damon S PerezDavid I Smith
Jan 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tim R MercerJohn S Mattick

❮ Previous
Next ❯

Citations

Jan 16, 2019·Cellular Oncology (Dordrecht)·Safieh Ebrahimi, Seyed Isaac Hashemy
Jun 22, 2020·Journal of Experimental & Clinical Cancer Research : CR·Katia GrillonePierfrancesco Tassone
May 21, 2020·Cancers·Mariateresa CasarottoElisabetta Fratta
Dec 5, 2019·World Journal of Gastrointestinal Oncology·Ya-Jun LuoJiang-Wei Xiao
Oct 28, 2019·Acta Biochimica Et Biophysica Sinica·Peihua LiuXiongbing Zu
Jun 9, 2019·Journal of Hematology & Oncology·Wen-Tao WangYue-Qin Chen
Oct 22, 2019·Frontiers in Oncology·Mercedes BermúdezRosalío Ramos-Payán
Aug 14, 2020·Cancers·Gonçalo Outeiro-PinhoCarmen Jerónimo
Apr 8, 2020·BioMed Research International·Shengli YuanDapeng Wu
Jul 2, 2020·International Journal of Molecular Sciences·Maria Letizia MottiMaria Vincenza Carriero
Dec 17, 2020·CA: a Cancer Journal for Clinicians·Lynne W ElmoreWilliam C Phelps
Jan 10, 2021·Seminars in Cancer Biology·Lei GuoYun Huang
Aug 23, 2020·Drug Discovery Today·Anindya DuttaSubhrangsu Chatterjee
Mar 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Wenxiao JiangXueqiong Zhu
Mar 24, 2021·Cellular Signalling·Qixuan CaiFan Li
Apr 4, 2021·International Journal of Molecular Sciences·Rosalin MishraJoan T Garrett
May 6, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bruna Maria de Sá PereiraMariana Maschietto
Aug 17, 2021·Expert Review of Clinical Immunology·Davide SelvestrelGiuliana Decorti
Apr 11, 2020·Life Sciences·Ke-Tao JinYing-Yu Ma

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides
dissection
transfection
xenograft
GTPase

Software Mentioned

Pharmaco
Glay
Cytoscape
miR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Cancer Journal
Muller FabbriGeorge A Calin
International Journal of Molecular Sciences
Ruth ZarateJesús Garcia-Foncillas
The New England Journal of Medicine
Chang-Zheng Chen
© 2022 Meta ULC. All rights reserved