The neumann type of pemphigus vegetans treated with combination of dapsone and steroid.

Annals of Dermatology
Young-Min SonJong-Rok Lee

Abstract

Pemphigus vegetans is a rare variant of pemphigus vulgaris and is characterized by vegetating lesions in the inguinal folds and mouth and by the presence of autoantibodies against desmoglein 3. Two clinical subtypes of pemphigus vegetans exist, which are initially characterized by flaccid bullae and erosions (the Neumann subtype) or pustules (the Hallopeau subtype). Both subtypes subsequently develop into hyperpigmented vegetative plaques with pustules and hypertrophic granulation tissue at the periphery of the lesions. Oral administration of corticosteroids alone does not always induce disease remission in patients with pemphigus vegetans. We report here on a 63-year-old woman with pemphigs vegetans. She had a 2-year history of vegetating, papillomatous plaques on the inguinal folds and erosions of the oral mucosa. The enzyme-linked immunosorbent assay was positive for anti-desmoglein 3, but it was negative for anti-desmoglein 1. She was initially treated with systemic steroid, but no improvement was observed. The patient was then successfully treated with a combination of systemic steroid and dapsone with a good clinical response.

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Citations

Jul 27, 2014·Actas dermo-sifiliográficas·P Mendes-BastosC Fernandes
Mar 13, 2014·La Presse médicale·Noama DahbiBadia Belaabidia
Sep 8, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A von KöckritzG Bonsmann
Jan 8, 2020·International Journal of Dermatology·Nohra GhaouiMazen Kurban
Oct 24, 2019·Anais Brasileiros De Dermatologia·Raisa Ilena Caranhas FeitozaSilvana de Albuquerque Damasceno Ferreira
Sep 22, 2020·The American Journal of Dermatopathology·Krista RonconeVernon J Forrester
Sep 8, 2017·Indian Journal of Dermatology, Venereology and Leprology·Tubanur Sarmiş ÇetinarslanSemra Kurutepe
Jan 1, 2019·Anais Brasileiros De Dermatologia·Raisa Ilena Caranhas FeitozaSilvana de Albuquerque Damasceno Ferreira
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonStanislav N Tolkachjov
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonJulia S Lehman
Oct 12, 2021·Experimental and Therapeutic Medicine·Victor-Vlad CostanMihaela Paula Toader

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
biopsy

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