The neural bases of the constructive nature of autobiographical memories studied with a self-paced fMRI design

Memory
Anne BotzungLilianne Manning

Abstract

In Conway and Pleydell-Pearce's model (2000), autobiographical memories are viewed as transitory mental representations, more often generated in an effortful way. An important claim of the model concerns the dynamic process that evolves over time, from the left prefrontal areas to posterior regions, to retrieve specific memories. The present work aims at investigating, using fMRI, the temporal distribution of effortful autobiographical memory construction. In addition, a self-paced design was implemented to elucidate the question of the timing window required to evoke recollections. The results showed a large pattern of brain regions, which included the two major poles of activation predicted by Conway and Pleydell-Pearce's model. Likewise, we were able to detect the earlier implication of the left dorso-lateral prefrontal cortex, by comparison with posterior structures, which seemed to confirm its involvement in the effortful retrieval process. Finally, the self-paced procedure allowed us to refine the timing window necessary to construct past events.

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Citations

Sep 18, 2012·Neuropsychological Rehabilitation·A ErnstL Manning
Oct 17, 2012·PloS One·Nathalie PhilippiFrédéric Blanc
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne BotzungKevin S Labar
Sep 8, 2011·Journal of Visualized Experiments : JoVE·Ekaterina DenkovaFlorin Dolcos
Jul 22, 2014·Journal of the Neurological Sciences·Alexandra ErnstLiliann Manning
Dec 31, 2010·Neurobiology of Aging·Peggy L St JacquesRoberto Cabeza
Jun 15, 2016·PloS One·Krystian Barzykowski, Agnieszka Niedźwieńska
Apr 30, 2014·World Journal of Radiology·Ekaterina J Denkova, Liliann Manning
Jul 19, 2017·Memory·Krystian Barzykowski, Agnieszka Niedźwieńska
Nov 24, 2020·Neurobiology of Learning and Memory·Hong-Zhou XuJing Yu
Aug 27, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Nathalie PhilippiFrédéric Blanc
Sep 7, 2019·Neuroscience and Biobehavioral Reviews·Maddalena BocciaCecilia Guariglia

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Software Mentioned

INQUISIT
Statistical Parametric Mapping ( SPM99
SPM
MarsBar

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