The neural basis of a deficit in abstract thinking in patients with schizophrenia

Psychiatry Research
Jooyoung OhJae-Jin Kim

Abstract

Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal...Continue Reading

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jul 1, 1974·Archives of General Psychiatry·M HarrowE Hanf
Oct 1, 1968·The American Journal of Orthopsychiatry·M BlankW H Bridger
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Jun 18, 2002·Nature Neuroscience·Stefan EverlingJohn Duncan
Apr 10, 2003·The Psychiatric Clinics of North America·Tonmoy Sharma, Lena Antonova
Mar 1, 1956·Journal of Abnormal Psychology·J H FLAVELL
Jul 19, 2005·Journal of Cognitive Neuroscience·J R BinderD A Medler
Jun 6, 2006·Brain Research·Adam E GreenKevin N Dunbar
May 25, 2007·Journal of the International Neuropsychological Society : JINS·Michael KiangMarta Kutas
Jul 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Mirjam SprongHerman van Engeland
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael Petrides, Deepak N Pandya
Apr 3, 2008·Human Brain Mapping·Frank Van Overwalle
Apr 19, 2008·Trends in Cognitive Sciences·Matthew M Botvinick
Jun 10, 2009·Brain Research·Kalina ChristoffBurkhard Mädler
Aug 13, 2009·Nature Reviews. Neuroscience·David Badre, Mark D'Esposito
Jan 29, 2010·Human Brain Mapping·Jing WangSvetlana V Shinkareva
Feb 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shinsuke KoikeKiyoto Kasai
Mar 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Michael J OwenNicholas Craddock
Nov 5, 2011·Social Neuroscience·Junghee LeeMichael F Green
Feb 15, 2013·Cerebral Cortex·Gabriella ViglioccoStefano F Cappa
Apr 10, 2013·Human Brain Mapping·Jing WangSvetlana V Shinkareva
May 10, 2013·Frontiers in Human Neuroscience·Tim Shallice, Richard P Cooper
Jan 28, 2014·Neuron·Robert C WilsonYael Niv
Apr 18, 2014·Behavioral and Brain Functions : BBF·Jooyoung OhJae-Jin Kim
Sep 18, 2014·Frontiers in Human Neuroscience·Ana SusacMaja Planinic

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