Nov 1, 2016

The neural basis of perceived intensity in natural and artificial touch

Science Translational Medicine
Emily L GraczykDustin J Tyler

Abstract

Electrical stimulation of sensory nerves is a powerful tool for studying neural coding because it can activate neural populations in ways that natural stimulation cannot. Electrical stimulation of the nerve has also been used to restore sensation to patients who have suffered the loss of a limb. We have used long-term implanted electrical interfaces to elucidate the neural basis of perceived intensity in the sense of touch. To this end, we assessed the sensory correlates of neural firing rate and neuronal population recruitment independently by varying two parameters of nerve stimulation: pulse frequency and pulse width. Specifically, two amputees, chronically implanted with peripheral nerve electrodes, performed each of three psychophysical tasks-intensity discrimination, magnitude scaling, and intensity matching-in response to electrical stimulation of their somatosensory nerves. We found that stimulation pulse width and pulse frequency had systematic, cooperative effects on perceived tactile intensity and that the artificial tactile sensations could be reliably matched to skin indentations on the intact limb. We identified a quantity we termed the activation charge rate (ACR), derived from stimulation parameters, that predic...Continue Reading

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  • Citations67

Citations

Mentioned in this Paper

In Silico
Nervousness
Psychometrics
Sensory Nerve
Neurons
Peripheral Nervous System
Nerve Fibers
Limb Structure
Man-Machine Systems
Neural Stem Cells

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