The Neural Correlates of Emotional Lability in Children with Autism Spectrum Disorder

Brain Connectivity
Randi H BennettAdriana Di Martino

Abstract

Autism spectrum disorder (ASD) is exceptionally heterogeneous in both clinical and physiopathological presentations. Clinical variability applies to ASD-specific symptoms and frequent comorbid psychopathology such as emotional lability (EL). To date, the physiopathological underpinnings of the co-occurrence of EL and ASD are unknown. As a first step, we examined within-ASD inter-individual variability of EL and its neuronal correlates using resting-state functional magnetic resonance imaging (R-fMRI). We analyzed R-fMRI data from 58 children diagnosed with ASD (5-12 years) in relation to the Conners' Parent Rating Scale EL index. We performed both an a priori amygdala region-of-interest (ROI) analysis, and a multivariate unbiased whole-brain data-driven approach. While no significant brain-behavior relationships were identified regarding amygdala intrinsic functional connectivity (iFC), multivariate whole-brain analyses revealed an extended functional circuitry centered on two regions: middle frontal gyrus (MFG) and posterior insula (PI). Follow-up parametric and nonparametric ROI-analyses of these regions revealed relationships between EL and MFG- and PI-iFC with default, salience, and visual networks suggesting that higher-or...Continue Reading

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Citations

Jan 22, 2020·Autism : the International Journal of Research and Practice·Hsiang-Yuan LinSusan Shur-Fen Gau
Jul 13, 2018·Frontiers in Human Neuroscience·Xia-An BiJianhua Dai
Feb 6, 2021·Autism Research : Official Journal of the International Society for Autism Research·Hillary K Schiltz, Brooke E Magnus
Jun 20, 2020·Biological Psychiatry·Seok-Jun HongAdriana Di Martino

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