The neural correlates of perceived energy levels in older adults with late-life depression

Brain Imaging and Behavior
Charlene L M LamTatia M C Lee

Abstract

Late-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrity of the corticospinal tract and determine its cognitive and functional correlates in older adults with late-life depression. Twenty-eight older adults with clinical depression and 23 healthy age-matched older adults participated in the study. The white matter volume and the white matter hyperintensities (WMHs) of the corticospinal tract, as well as the global WMHs, were measured. Psychomotor processing speed, severity of depression, perceived levels of energy and physical functioning were measured to examine the relationships among the correlates in the depressed participants. The right corticospinal tract volume was significantly higher in depressed older adults relative to healthy controls. Moreover, the right corticospinal tract volume was significantly associated with the overall severity of depression and accounted for 17% of its variance. It further attenuated the relationship between the severity of depression and perceived l...Continue Reading

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Citations

Feb 9, 2021·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Xiaofu HeBret R Rutherford

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Software Mentioned

SPSS
Matlab
VBM
Insight Segmentation and Registration Toolkit ( ITK
SPM12
DARTEL
PROCESS
Statistical Parametric Mapping

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