The neural correlates of social anxiety disorder and response to pharmacotherapy

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
C D KiltsCharles B Nemeroff

Abstract

This study attempted to define further the neural processing events underlying social anxiety in patients with social anxiety disorder (SAD) and their response to pharmacotherapy. Social anxiety-related changes in regional cerebral blood flow were defined by [15O]H2 positron emission tomography (PET) in medication-free individuals with generalized SAD (gSAD), and age- and sex-matched comparison subjects, and analyzed using a linear mixed effects model. PET studies were again acquired in the gSAD individuals following an 8-week, flexible dose treatment trial of nefazodone. Both script-guided mental imagery of an anxiogenic social situation and a confrontational mental arithmetic task were associated with marked increases in self-rated anxiety in both subject groups. For gSAD subjects, social anxiety induced by guided mental imagery was associated with increased activity in the left postcentral gyrus and lenticulate, and the right inferior frontal and middle temporal gyri. Social anxiety induced by the mental arithmetic task was associated with activation of the medial and left dorsolateral prefrontal cortex, cerebellum, thalamus, insula, and ventral striatum. Both tasks were associated with relative decreases in activity in the ...Continue Reading

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Mar 4, 2009·Archives of General Psychiatry·Katja BeesdoDaniel S Pine
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Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
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