The Neural Correlates of the Clock-Drawing Test in Healthy Aging

Frontiers in Human Neuroscience
Natasha A TalwarTom A Schweizer

Abstract

Importance: The clock-drawing test (CDT) is an important neurocognitive assessment tool, widely used as a screening test for dementia. Behavioral performance on the test has been studied extensively, but there is scant literature on the underlying neural correlates. Purpose: To administer the CDT naturalistically to a healthy older aging population in an MRI environment, and characterize the brain activity associated with test completion. Main Outcome and Measure: Blood-oxygen-level dependent (BOLD) functional MRI was conducted as participants completed the CDT using novel tablet technology. Brain activity during CDT performance was contrasted to rest periods of visual fixation. Performance on the CDT was evaluated using a standardized scoring system (Rouleau score) and time to test completion. To assess convergent validity, performance during fMRI was compared to performance on a standard paper version of the task, administered in a psychometric testing room. Results: Study findings are reported for 33 cognitively healthy older participants aged 52-85. Activation was observed in the bilateral frontal, occipital and parietal lobes as well as the supplementary motor area and precentral gyri. Increased age was significantly corre...Continue Reading

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Citations

May 13, 2020·PloS One·Natasha TalwarTom A Schweizer
Sep 15, 2019·Aging Clinical and Experimental Research·Jennapher Lingo VanGilderSydney Y Schaefer
Jul 10, 2021·Applied Neuropsychology. Adult·Maria Chiara FastameMassimiliano Pau

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Software Mentioned

AFNI 3dmerge
Analysis of Functional Neuroimages ( AFNI )
NPAIRS
PHYCAA +
AFNI 3dvolreg
SPIKECOR
Prime
FMRIB Software Library ( FSL )
AFNI 3dTshift

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