The Neural Mechanisms of Sexually Dimorphic Aggressive Behaviors

Trends in Genetics : TIG
Koichi HashikawaDayu Lin

Abstract

Aggression is a fundamental social behavior that is essential for competing for resources and protecting oneself and families in both males and females. As a result of natural selection, aggression is often displayed differentially between the sexes, typically at a higher level in males than females. Here, we highlight the behavioral differences between male and female aggression in rodents. We further outline the aggression circuits in males and females, and compare their differences at each circuit node. Lastly, we summarize our current understanding regarding the generation of sexually dimorphic aggression circuits during development and their maintenance during adulthood. In both cases, gonadal steroid hormones appear to play crucial roles in differentiating the circuits by impacting on the survival, morphology, and intrinsic properties of relevant cells. Many other factors, such as environment and experience, may also contribute to sex differences in aggression and remain to be investigated in future studies.

Citations

Aug 29, 2019·Frontiers in Systems Neuroscience·Joel D HahnB Glenn Stanley
May 21, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Bruno Gegenhuber, Jessica Tollkuhn
Jul 11, 2020·Psychopharmacology·Nastacia L GoodwinSam A Golden
Oct 14, 2020·Nature Neuroscience·Julieta E Lischinsky, Dayu Lin
Nov 4, 2020·ELife·Catherine E SchretterGerald M Rubin
Feb 13, 2021·The Journal of Comparative Neurology·Da-Jiang ZhengSteven M Phelps
Feb 16, 2019·Brain Research·Steven C KyleMathew A Cooper
Mar 12, 2021·Neuron·Dongyu WeiDayu Lin
Mar 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Kris H SabbiMartin N Muller
Mar 27, 2021·Genes, Brain, and Behavior·Hannah D FulenwiderAndrey E Ryabinin
May 20, 2021·Nature Communications·Vinícius Elias de Moura OliveiraInga D Neumann
Aug 24, 2021·Frontiers in Behavioral Neuroscience·Maria Jesus HerreroJoshua G Corbin

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