PMID: 6159457Nov 1, 1980Paper

The neuritogenicity and encephalitogenicity of P2 in the rat, guinea-pig and rabbit

Journal of the Neurological Sciences
M Kadlubowski, R A Hughes

Abstract

In inbred Lewis rats, P2 basic protein from bovine peripheral nervous system (PNS) myelin produced experimental allergic neuritis (EAN) without involvement of the brain or spinal cord. In guinea-pigs, bovine P2 did not produce EAN but large doses produced mild experimental allergic encephalomyelitis (EAE). In rabbits, bovine P2 produced both mild EAE and EAN. Human P2 produced severe EAN in the Lewis rat, but only mild EAN with quite marked EAE in the guinea-pig. Material cross-reacting with bovine P on immunodiffusion was identified in the extracts from the nerves of all three species but only in the spinal cord of the guinea-pig and rabbit, not in the rat spinal cord. The species differences in response to immunisation with P2 cannot be simply explained by the presence or absence of P2 in their PNS or CNS, but may reflect differences in the immune response.

References

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Citations

Dec 1, 1983·Journal of the Neurological Sciences·K SaidaH Nishitani
Jun 1, 1987·Journal of the Neurological Sciences·C M Poser
Jan 1, 1988·Journal of the Neurological Sciences·H WiethölterK Wessel
Sep 1, 1992·Journal of the Neurological Sciences·C M Poser
Aug 1, 1982·Journal of Neuroimmunology·C M Poser, P O Behan
Jan 13, 2001·Clinical Neurology and Neurosurgery·C M Poser
Apr 6, 2007·Nature Clinical Practice. Neurology·Gerd Meyer zu HörsteBernd C Kieseier
Mar 30, 2013·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Ivan AdamecMario Habek
Jul 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·R A HughesS Leibowitz
May 12, 2006·Neurological Research·Kourosh RezaniaBetty Soliven
Nov 11, 2008·Reproduction in Domestic Animals = Zuchthygiene·F J F Sant'AnaC G Barbeito
Jul 28, 2007·Journal of the Neurological Sciences·Charles M Poser
Mar 16, 2004·Acta Neurologica Scandinavica·C M Poser
Sep 8, 2007·Muscle & Nerve·Gerd Meyer zu HörsteBernd C Kieseier
Mar 14, 2009·Reproduction in Domestic Animals = Zuchthygiene·O J KooB C Lee
May 1, 1989·Neuropathology and Applied Neurobiology·A M AdamW A Taylor
Dec 1, 1982·Journal of Neurochemistry·M SuzukiK Uyemura
Jan 3, 2006·Clinical Neurology and Neurosurgery·Vesna V Brinar, Charles M Poser
Mar 2, 2010·Expert Review of Neurotherapeutics·Vesna V Brinar, Mario Habek
Jul 1, 1985·Muscle & Nerve·R A HughesS Brostoff
Dec 1, 1993·Journal of Neurochemistry·C A WellsD A Kirschner
Mar 1, 1983·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·B KlingebornR A Hughes
Oct 1, 1982·Acta Neurologica Scandinavica·C M Poser

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