The neurochemical substrates of habitual and goal-directed control.

Translational Psychiatry
Valerie VoonValtteri Kaasinen

Abstract

Our daily decisions are governed by the arbitration between goal-directed and habitual strategies. However, the neurochemical basis of this arbitration is unclear. We assessed the contribution of dopaminergic, serotonergic, and opioidergic systems to this balance across reward and loss domains. Thirty-nine participants (17 healthy controls, 15 patients with pathological gambling, and 7 with binge eating disorder) underwent positron emission tomography (PET) imaging with [18F]FDOPA, [11C]MADAM and [11C]carfentanil to assess presynaptic dopamine, and serotonin transporter and mu-opioid receptor binding potential. Separately, participants completed a modified two-step task, which quantifies the degree to which decision-making is influenced by goal-directed or habitual strategies. All participants completed a version with reward outcomes; healthy controls additionally completed a version with loss outcomes. In the context of rewarding outcomes, we found that greater serotonin transporter binding potential in prefrontal regions was associated with habitual control, while greater serotonin transporter binding potential in the putamen was marginally associated with goal-directed control; however, the findings were no longer significan...Continue Reading

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Citations

Apr 12, 2021·Journal of Pediatric Urology·Samuel Gomes CardosoUbirajara Barroso
Jun 23, 2021·The American Journal of Psychiatry·Camilla L NordTim Dalgleish

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Software Mentioned

Free Surfer
Statistical Parametric Mapping SPM8
FreeSurfer
Matlab

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